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Research Article

The Mechanism of Release of P-TEFb and HEXIM1 from the 7SK snRNP by Viral and Cellular Activators Includes a Conformational Change in 7SK

  • Brian J. Krueger,

    Affiliation: Molecular and Cellular Biology Program, University of Iowa, Iowa City, Iowa, United States of America

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  • Katayoun Varzavand,

    Affiliation: Biochemistry Department, University of Iowa, Iowa City, Iowa, United States of America

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  • Jeffrey J. Cooper,

    Affiliation: Biochemistry Department, University of Iowa, Iowa City, Iowa, United States of America

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  • David H. Price mail

    david-price@uiowa.edu

    Affiliations: Molecular and Cellular Biology Program, University of Iowa, Iowa City, Iowa, United States of America, Biochemistry Department, University of Iowa, Iowa City, Iowa, United States of America

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  • Published: August 23, 2010
  • DOI: 10.1371/journal.pone.0012335

About the Authors

Brian J. Krueger, David H. Price
Molecular and Cellular Biology Program, University of Iowa, Iowa City, Iowa, United States of America
Katayoun Varzavand, Jeffrey J. Cooper, David H. Price
Biochemistry Department, University of Iowa, Iowa City, Iowa, United States of America

Corresponding Author

Email: david-price@uiowa.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BJK DHP. Performed the experiments: BJK KV JJC. Analyzed the data: BJK DHP. Wrote the paper: BJK DHP. Oversaw the project and advised all others: DHP.