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Research Article

Human Neural Stem Cells Differentiate and Promote Locomotor Recovery in an Early Chronic Spinal coRd Injury NOD-scid Mouse Model

  • Desirée L. Salazar,

    Affiliations: Department of Anatomy and Neurobiology, University of California Irvine, Irvine, California, United States of America, Sue and Bill Gross Stem Cell Research Center, University of California Irvine, Irvine, California, United States of America, Reeve-Irvine Research Center, University of California Irvine, Irvine, California, United States of America

    Current address: Department of Cellular and Molecular Medicine, Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, California, United States of America

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  • Nobuko Uchida,

    Affiliation: StemCells, Inc., Palo Alto, California, United States of America

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  • Frank P. T. Hamers,

    Affiliation: Rehabilitation Hospital Tolbrug, 's Hertogenbosch, The Netherlands

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  • Brian J. Cummings equal contributor,

    equal contributor Contributed equally to this work with: Brian J. Cummings, Aileen J. Anderson

    Affiliations: Sue and Bill Gross Stem Cell Research Center, University of California Irvine, Irvine, California, United States of America, Reeve-Irvine Research Center, University of California Irvine, Irvine, California, United States of America, Department of Physical Medicine and Rehabilitation, University of California Irvine, Irvine, California United States of America

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  • Aileen J. Anderson equal contributor mail

    equal contributor Contributed equally to this work with: Brian J. Cummings, Aileen J. Anderson

    aja@uci.edu

    Affiliations: Department of Anatomy and Neurobiology, University of California Irvine, Irvine, California, United States of America, Sue and Bill Gross Stem Cell Research Center, University of California Irvine, Irvine, California, United States of America, Reeve-Irvine Research Center, University of California Irvine, Irvine, California, United States of America, Department of Physical Medicine and Rehabilitation, University of California Irvine, Irvine, California United States of America

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  • Published: August 18, 2010
  • DOI: 10.1371/journal.pone.0012272

About the Authors

Desirée L. Salazar, Aileen J. Anderson
Department of Anatomy and Neurobiology, University of California Irvine, Irvine, California, United States of America
Desirée L. Salazar, Brian J. Cummings, Aileen J. Anderson
Sue and Bill Gross Stem Cell Research Center, University of California Irvine, Irvine, California, United States of America
Desirée L. Salazar, Brian J. Cummings, Aileen J. Anderson
Reeve-Irvine Research Center, University of California Irvine, Irvine, California, United States of America
Nobuko Uchida
StemCells, Inc., Palo Alto, California, United States of America
Frank P. T. Hamers
Rehabilitation Hospital Tolbrug, 's Hertogenbosch, The Netherlands
Brian J. Cummings, Aileen J. Anderson
Department of Physical Medicine and Rehabilitation, University of California Irvine, Irvine, California United States of America

Corresponding Author

Email: aja@uci.edu

Competing Interests

Nobuko Uchida is a paid employee of StemCells, Inc. Aileen J. Anderson has served as a paid consultant to StemCells, Inc. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: DLS NU BJC AJA. Performed the experiments: DLS BJC. Analyzed the data: DLS BJC AJA. Contributed reagents/materials/analysis tools: NU FPTH. Wrote the paper: DLS BJC AJA.