About the Authors

Gregory J. Hather

Affiliations Bioinformatics & High-throughput Analysis Laboratory, Seattle Children's Research Institute, Seattle, Washington, United States of America, High-throughput Analysis Core, Seattle Children's Research Institute, Seattle, Washington, United States of America

Winston Haynes

Affiliations Bioinformatics & High-throughput Analysis Laboratory, Seattle Children's Research Institute, Seattle, Washington, United States of America, Hendrix College, Conway, Arkansas, United States of America

Roger Higdon

Affiliations Bioinformatics & High-throughput Analysis Laboratory, Seattle Children's Research Institute, Seattle, Washington, United States of America, High-throughput Analysis Core, Seattle Children's Research Institute, Seattle, Washington, United States of America, Predictive Analytics, Seattle Children's Hospital, Seattle, Washington, United States of America

Natali Kolker

Affiliations High-throughput Analysis Core, Seattle Children's Research Institute, Seattle, Washington, United States of America, Predictive Analytics, Seattle Children's Hospital, Seattle, Washington, United States of America

Elizabeth A. Stewart

Affiliations Bioinformatics & High-throughput Analysis Laboratory, Seattle Children's Research Institute, Seattle, Washington, United States of America, High-throughput Analysis Core, Seattle Children's Research Institute, Seattle, Washington, United States of America

Peter Arzberger

Affiliation Center for Research on BioSystems, University of California San Diego, San Diego, California, United States of America

Patrick Chain

Affiliations Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America, Metagenomics Program, Joint Genome Institute, Walnut Creek, California, United States of America, Center for Microbial Ecology, Michigan State University, East Lansing, Michigan, United States of America

Dawn Field

Affiliation Centre for Ecology and Hydrology, Natural Environmental Research Council, Oxford, United Kingdom

B. Robert Franza

Affiliations MYOONET, Inc., Seattle, Washington, United States of America, Department of Bioengineering, University of Washington, Seattle, Washington, United States of America

Biaoyang Lin

Affiliations Zhejiang-California International Nanosystems Institute, Zhejiang University, Hangzhou, China, Swedish Neuroscience Institute, Swedish Medical Center, Seattle, Washington, United States of America, Department of Urology, University of Washington, Seattle, Washington, United States of America

Folker Meyer

Affiliations Argonne National Laboratory, Argonne, Illinois, United States of America, University of Chicago, Chicago, Illinois, United States of America

Vural Ozdemir

Affiliation Department of Human Genetics, Faculty of Medicine, McGill University, Montreal, Quebec, Canada

Charles V. Smith

Affiliations Center for Developmental Therapeutics, Seattle Children's Research Institute, Seattle, Washington, United States of America, Department of Pediatrics, University of Washington, Seattle, Washington, United States of America

Gerald van Belle

Affiliations Department of Biostatistics, University of Washington, Seattle, Washington, United States of America, Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, United States of America

John Wooley

Affiliation Center for Research on BioSystems, University of California San Diego, San Diego, California, United States of America

Eugene Kolker

Eugene.Kolker@seattlechildrens.org

Affiliations Bioinformatics & High-throughput Analysis Laboratory, Seattle Children's Research Institute, Seattle, Washington, United States of America, High-throughput Analysis Core, Seattle Children's Research Institute, Seattle, Washington, United States of America, Predictive Analytics, Seattle Children's Hospital, Seattle, Washington, United States of America, Department of Medical Education and Biomedical Informatics, University of Washington, Seattle, Washington, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Analyzed the data: GJH WAH RH NK EAS PA PC DF BRF BL FM VO CVS GvB JCW EK. Wrote the paper: GJH WAH RH EAS EK. Made significant contributions to the interpretation of the results: NK PA PC DF BRF BL FM VO CVS GvB JCW. Helped decide the scope of the paper: NK PA PC DF BRF BL FM VO CVS GvB JCW. Suggested analysis to include: NK PA PC DF BRF FM CVS GvB JCW. Conceived of the analysis and directed the project: EK.