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Research Article

Insights in 17β-HSD1 Enzyme Kinetics and Ligand Binding by Dynamic Motion Investigation

  • Matthias Negri,

    Affiliations: Pharmaceutical and Medicinal Chemistry, Saarland University, Saarbrücken, Germany, Helmholtz Institute for Pharmaceutical Research Saarland, Saarbrücken, Germany

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  • Maurizio Recanatini,

    Affiliation: Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy

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  • Rolf W. Hartmann mail

    rwh@mx.uni-saarland.de

    Affiliations: Pharmaceutical and Medicinal Chemistry, Saarland University, Saarbrücken, Germany, Helmholtz Institute for Pharmaceutical Research Saarland, Saarbrücken, Germany

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  • Published: August 10, 2010
  • DOI: 10.1371/journal.pone.0012026

About the Authors

Matthias Negri, Rolf W. Hartmann
Pharmaceutical and Medicinal Chemistry, Saarland University, Saarbrücken, Germany
Matthias Negri, Rolf W. Hartmann
Helmholtz Institute for Pharmaceutical Research Saarland, Saarbrücken, Germany
Maurizio Recanatini
Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy

Corresponding Author

Email: rwh@mx.uni-saarland.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MN. Performed the experiments: MN. Analyzed the data: MN. Wrote the paper: MN MR RWH. Supervised MN: MR. Supervised MN.