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Research Article

Calcineurin Interacts with PERK and Dephosphorylates Calnexin to Relieve ER Stress in Mammals and Frogs

  • Mariana Bollo equal contributor,

    equal contributor Contributed equally to this work with: Mariana Bollo, R. Madelaine Paredes

    Affiliation: Instituto de Investigación Médica Mercedes y Martín Ferreyra (INIMEC CONICET), Córdoba, Argentina

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  • R. Madelaine Paredes equal contributor,

    equal contributor Contributed equally to this work with: Mariana Bollo, R. Madelaine Paredes

    Affiliation: Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

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  • Deborah Holstein,

    Affiliation: Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

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  • Nadezhda Zheleznova,

    Affiliation: Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

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  • Patricia Camacho,

    Affiliation: Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

    X
  • James D. Lechleiter mail

    Lechleiter@uthscsa.edu

    Affiliation: Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

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  • Published: August 05, 2010
  • DOI: 10.1371/journal.pone.0011925

About the Authors

Mariana Bollo
Instituto de Investigación Médica Mercedes y Martín Ferreyra (INIMEC CONICET), Córdoba, Argentina
R. Madelaine Paredes, Deborah Holstein, James D. Lechleiter
Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
Nadezhda Zheleznova, Patricia Camacho
Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

Corresponding Author

Email: Lechleiter@uthscsa.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MB RMP PC JL. Performed the experiments: MB RMP DH NZ. Analyzed the data: MB RMP DH NZ JL. Contributed reagents/materials/analysis tools: MB RMP. Wrote the paper: MB PC JL. Edited the manuscript, wrote figure legends, and helped with the outline of the paper: RMP.