About the Authors

Shengxi Guan

Affiliation New England Biolabs, Inc., Ipswich, Massachusetts, United States of America

Aine Blanchard

Affiliation New England Biolabs, Inc., Ipswich, Massachusetts, United States of America

Penghua Zhang

Affiliation New England Biolabs, Inc., Ipswich, Massachusetts, United States of America

Zhenyu Zhu

zhuz@neb.com

Affiliation New England Biolabs, Inc., Ipswich, Massachusetts, United States of America

Competing Interests

The engineered products, BtsI-1 and Nb.BtsI-1, which can be commercial products, are already covered by pending patent application. This fact does not alter the authors' adherence to all the Plos ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: ZZ. Performed the experiments: SG AB ZZ. Analyzed the data: SG AB ZZ. Contributed reagents/materials/analysis tools: PZ. Wrote the paper: SG AB ZZ.