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Research Article

Novel Antibodies Reveal Inclusions Containing Non-Native SOD1 in Sporadic ALS Patients

  • Karin Forsberg,

    Affiliations: Department of Medical Biosciences, Umeå University, Umeå, Sweden, Department of Pathology, Umeå University, Umeå, Sweden

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  • P. Andreas Jonsson,

    Affiliations: Department of Medical Biosciences, Umeå University, Umeå, Sweden, Department of Clinical Chemistry, Umeå University, Umeå, Sweden

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  • Peter M. Andersen,

    Affiliation: Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden

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  • Daniel Bergemalm,

    Affiliations: Department of Medical Biosciences, Umeå University, Umeå, Sweden, Department of Clinical Chemistry, Umeå University, Umeå, Sweden

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  • Karin S. Graffmo,

    Affiliations: Department of Medical Biosciences, Umeå University, Umeå, Sweden, Department of Pathology, Umeå University, Umeå, Sweden

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  • Magnus Hultdin,

    Affiliations: Department of Medical Biosciences, Umeå University, Umeå, Sweden, Department of Pathology, Umeå University, Umeå, Sweden

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  • Johan Jacobsson,

    Affiliation: Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden

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  • Roland Rosquist,

    Affiliation: Department of Molecular Biology, Umeå University, Umeå, Sweden

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  • Stefan L. Marklund,

    Affiliations: Department of Medical Biosciences, Umeå University, Umeå, Sweden, Department of Clinical Chemistry, Umeå University, Umeå, Sweden

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  • Thomas Brännström mail

    thomas.brannstrom@medbio.umu.se

    Affiliations: Department of Medical Biosciences, Umeå University, Umeå, Sweden, Department of Pathology, Umeå University, Umeå, Sweden

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  • Published: July 14, 2010
  • DOI: 10.1371/journal.pone.0011552

About the Authors

Karin Forsberg, P. Andreas Jonsson, Daniel Bergemalm, Karin S. Graffmo, Magnus Hultdin, Stefan L. Marklund, Thomas Brännström
Department of Medical Biosciences, Umeå University, Umeå, Sweden
Karin Forsberg, Karin S. Graffmo, Magnus Hultdin, Thomas Brännström
Department of Pathology, Umeå University, Umeå, Sweden
P. Andreas Jonsson, Daniel Bergemalm, Stefan L. Marklund
Department of Clinical Chemistry, Umeå University, Umeå, Sweden
Peter M. Andersen, Johan Jacobsson
Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden
Roland Rosquist
Department of Molecular Biology, Umeå University, Umeå, Sweden

Corresponding Author

Email: thomas.brannstrom@medbio.umu.se

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PMA SLM TB. Performed the experiments: KF PAJ DB RR SLM TB. Analyzed the data: KF PAJ PMA SLM TB. Wrote the paper: KF PAJ PMA SLM TB. Collected the research material: KF PAJ PMA KSG MH JJ TB.