About the Authors

Asimina Hiona

Current address: National Hellenic Research Foundation, Institute of Biological Research and Biotechnology, Athens, Greece

Affiliation Division of Biology of Aging, Department of Aging and Geriatric Research, Institute on Aging, College of Medicine, University of Florida, Gainesville, Florida, United States of America

Alberto Sanz

Affiliation Mitochondrial Gene Expression and Disease Group. Institute of Medical Technology and Tampere University Hospital, University of Tampere, Tampere, Finland

Gregory C. Kujoth

Affiliation Department of Genetics and Medical Genetics, University of Wisconsin, Madison, Wisconsin, United States of America

Reinald Pamplona

Affiliation Department of Experimental Medicine, University of Lleida-Institut de Recerca Biomèdica de Lleida, Lleida, Spain

Arnold Y. Seo

Affiliation Division of Biology of Aging, Department of Aging and Geriatric Research, Institute on Aging, College of Medicine, University of Florida, Gainesville, Florida, United States of America

Tim Hofer

Affiliation Division of Biology of Aging, Department of Aging and Geriatric Research, Institute on Aging, College of Medicine, University of Florida, Gainesville, Florida, United States of America

Shinichi Someya

Affiliations Department of Genetics and Medical Genetics, University of Wisconsin, Madison, Wisconsin, United States of America, Department of Applied Biological Chemistry, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

Takuya Miyakawa

Affiliation Department of Applied Biological Chemistry, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

Chie Nakayama

Affiliation Department of Applied Biological Chemistry, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

Alejandro K. Samhan-Arias

Affiliation Department of Biochemistry and Molecular Biology, Faculty of Sciences, University of Extremadura, Badajoz, Spain

Stephane Servais

Affiliation Division of Biology of Aging, Department of Aging and Geriatric Research, Institute on Aging, College of Medicine, University of Florida, Gainesville, Florida, United States of America

Jamie L. Barger

Affiliation LifeGen Technologies, LLC, Madison, Wisconsin, United States of America

Manuel Portero-Otín

Affiliation Department of Experimental Medicine, University of Lleida-Institut de Recerca Biomèdica de Lleida, Lleida, Spain

Masaru Tanokura

Affiliation Department of Applied Biological Chemistry, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

Tomas A. Prolla

taprolla@wisc.edu (TAP); cleeuwen@aging.ufl.edu (CL)

Affiliation Department of Genetics and Medical Genetics, University of Wisconsin, Madison, Wisconsin, United States of America

Christiaan Leeuwenburgh

taprolla@wisc.edu (TAP); cleeuwen@aging.ufl.edu (CL)

Affiliation Division of Biology of Aging, Department of Aging and Geriatric Research, Institute on Aging, College of Medicine, University of Florida, Gainesville, Florida, United States of America

Competing Interests

GCK and TAP were awarded United States patent 7,126,040 for the PolgD257A mouse model. TAP is a co-founder and scientific consultant for LifeGen Technologies, specializing in the application of DNA microarray analysis to analyzing nutraceutical interventions in aging. Dr. Barger of LifeGen Technologies was involved with analysis of gene expression data from microarray experiments. This does not alter the authors' adherence to all of the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AH AS GCK S. Someya S. Servais MT TAP CL. Performed the experiments: AH AS RP AYS TH S. Someya TM CN AKSA MPO. Analyzed the data: AH AS GCK RP AYS TH S. Someya TM CN AKSA JLB MPO. Contributed reagents/materials/analysis tools: AH AS GCK RP AYS TH S. Someya TM CN AKSA S. Servais MPO MT TAP. Wrote the paper: AH AS GCK S. Someya TAP CL.