About the Authors
- Asimina Hiona
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Current address: National Hellenic Research Foundation, Institute of Biological Research and Biotechnology, Athens, Greece
Affiliation Division of Biology of Aging, Department of Aging and Geriatric Research, Institute on Aging, College of Medicine, University of Florida, Gainesville, Florida, United States of America
- Alberto Sanz
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Affiliation Mitochondrial Gene Expression and Disease Group. Institute of Medical Technology and Tampere University Hospital, University of Tampere, Tampere, Finland
- Gregory C. Kujoth
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Affiliation Department of Genetics and Medical Genetics, University of Wisconsin, Madison, Wisconsin, United States of America
- Reinald Pamplona
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Affiliation Department of Experimental Medicine, University of Lleida-Institut de Recerca Biomèdica de Lleida, Lleida, Spain
- Arnold Y. Seo
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Affiliation Division of Biology of Aging, Department of Aging and Geriatric Research, Institute on Aging, College of Medicine, University of Florida, Gainesville, Florida, United States of America
- Tim Hofer
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Affiliation Division of Biology of Aging, Department of Aging and Geriatric Research, Institute on Aging, College of Medicine, University of Florida, Gainesville, Florida, United States of America
- Shinichi Someya
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Affiliations Department of Genetics and Medical Genetics, University of Wisconsin, Madison, Wisconsin, United States of America, Department of Applied Biological Chemistry, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
- Takuya Miyakawa
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Affiliation Department of Applied Biological Chemistry, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
- Chie Nakayama
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Affiliation Department of Applied Biological Chemistry, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
- Alejandro K. Samhan-Arias
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Affiliation Department of Biochemistry and Molecular Biology, Faculty of Sciences, University of Extremadura, Badajoz, Spain
- Stephane Servais
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Affiliation Division of Biology of Aging, Department of Aging and Geriatric Research, Institute on Aging, College of Medicine, University of Florida, Gainesville, Florida, United States of America
- Jamie L. Barger
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Affiliation LifeGen Technologies, LLC, Madison, Wisconsin, United States of America
- Manuel Portero-Otín
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Affiliation Department of Experimental Medicine, University of Lleida-Institut de Recerca Biomèdica de Lleida, Lleida, Spain
- Masaru Tanokura
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Affiliation Department of Applied Biological Chemistry, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
- Tomas A. Prolla
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* E-mail: taprolla@wisc.edu (TAP); cleeuwen@aging.ufl.edu (CL)
Affiliation Department of Genetics and Medical Genetics, University of Wisconsin, Madison, Wisconsin, United States of America
- Christiaan Leeuwenburgh
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* E-mail: taprolla@wisc.edu (TAP); cleeuwen@aging.ufl.edu (CL)
Affiliation Division of Biology of Aging, Department of Aging and Geriatric Research, Institute on Aging, College of Medicine, University of Florida, Gainesville, Florida, United States of America
Competing Interests
GCK and TAP were awarded United States patent 7,126,040 for the PolgD257A mouse model. TAP is a co-founder and scientific consultant for LifeGen Technologies, specializing in the application of DNA microarray analysis to analyzing nutraceutical interventions in aging. Dr. Barger of LifeGen Technologies was involved with analysis of gene expression data from microarray experiments. This does not alter the authors' adherence to all of the PLoS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: AH AS GCK S. Someya S. Servais MT TAP CL. Performed the experiments: AH AS RP AYS TH S. Someya TM CN AKSA MPO. Analyzed the data: AH AS GCK RP AYS TH S. Someya TM CN AKSA JLB MPO. Contributed reagents/materials/analysis tools: AH AS GCK RP AYS TH S. Someya TM CN AKSA S. Servais MPO MT TAP. Wrote the paper: AH AS GCK S. Someya TAP CL.