VEGF Stimulates RCAN1.4 Expression in Endothelial Cells via a Pathway Requiring Ca2+/Calcineurin and Protein Kinase C-δ

Katherine Holmes; Elinor Chapman; Violaine See; Michael J. Cross

doi:10.1371/journal.pone.0011435

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Open Access

Peer-reviewed

Research Article

VEGF Stimulates RCAN1.4 Expression in Endothelial Cells via a Pathway Requiring Ca²⁺/Calcineurin and Protein Kinase C-δ

Katherine Holmes,

Affiliation Department of Pharmacology and Therapeutics, School of Biomedical Sciences, University of Liverpool, Liverpool, United Kingdom
⨯
Elinor Chapman,

Affiliations Department of Pharmacology and Therapeutics, School of Biomedical Sciences, University of Liverpool, Liverpool, United Kingdom, North West Cancer Research Institute, School of Biological Sciences, Bangor University, Bangor, United Kingdom
⨯
Violaine See,

Affiliation School of Biological Sciences, University of Liverpool, Liverpool, United Kingdom
⨯
Michael J. Cross

* E-mail: m.j.cross@liv.ac.uk

Affiliation Department of Pharmacology and Therapeutics, School of Biomedical Sciences, University of Liverpool, Liverpool, United Kingdom
⨯

VEGF Stimulates RCAN1.4 Expression in Endothelial Cells via a Pathway Requiring Ca²⁺/Calcineurin and Protein Kinase C-δ

Katherine Holmes,
Elinor Chapman,
Violaine See,
Michael J. Cross

Published: July 6, 2010
https://doi.org/10.1371/journal.pone.0011435

About the Authors

Katherine Holmes

Affiliation Department of Pharmacology and Therapeutics, School of Biomedical Sciences, University of Liverpool, Liverpool, United Kingdom

Elinor Chapman

Affiliations Department of Pharmacology and Therapeutics, School of Biomedical Sciences, University of Liverpool, Liverpool, United Kingdom, North West Cancer Research Institute, School of Biological Sciences, Bangor University, Bangor, United Kingdom

Violaine See

Affiliation School of Biological Sciences, University of Liverpool, Liverpool, United Kingdom

Michael J. Cross

* E-mail: m.j.cross@liv.ac.uk

Affiliation Department of Pharmacology and Therapeutics, School of Biomedical Sciences, University of Liverpool, Liverpool, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KH MJC. Performed the experiments: KH EC VS. Analyzed the data: KH EC VS. Contributed reagents/materials/analysis tools: VS. Wrote the paper: KH MJC.

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Small interfering RNA
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Phosphorylation
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Transfection
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Endothelial cells
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Gene expression
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Morphogenesis
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Collagens
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VEGF signaling
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