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Research Article

Empiric Antibiotic Therapy for Staphylococcus aureus Bacteremia May Not Reduce In-Hospital Mortality: A Retrospective Cohort Study

  • Marin L. Schweizer mail,

    marin-schweizer@uiowa.edu

    Affiliations: Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America

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  • Jon P. Furuno,

    Affiliation: Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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  • Anthony D. Harris,

    Affiliation: Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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  • J. Kristie Johnson,

    Affiliation: Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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  • Michelle D. Shardell,

    Affiliation: Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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  • Jessina C. McGregor,

    Affiliation: Department of Pharmacy Practice, College of Pharmacy, Oregon Health and Science University, Portland, Oregon, United States of America

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  • Kerri A. Thom,

    Affiliation: Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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  • George Sakoulas,

    Affiliation: Sharp Memorial Hospital, San Diego, California, United States of America

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  • Eli N. Perencevich

    Affiliations: Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America, Iowa City VA Medical Center, Iowa City, Iowa, United States of America

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  • Published: July 02, 2010
  • DOI: 10.1371/journal.pone.0011432

About the Authors

Marin L. Schweizer, Jon P. Furuno, Anthony D. Harris, Michelle D. Shardell, Kerri A. Thom
Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
Marin L. Schweizer, Eli N. Perencevich
Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America
J. Kristie Johnson
Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
Jessina C. McGregor
Department of Pharmacy Practice, College of Pharmacy, Oregon Health and Science University, Portland, Oregon, United States of America
George Sakoulas
Sharp Memorial Hospital, San Diego, California, United States of America
Eli N. Perencevich
Iowa City VA Medical Center, Iowa City, Iowa, United States of America

Corresponding Author

Email: marin-schweizer@uiowa.edu

Competing Interests

MLS and ENP have received research support from Pfizer, Inc. GS is a consultant for Astellas, Cubist, Pfizer, Ortho-McNeal, has served as a speaker for Astellas, Cubist, Pfizer and has received research support from Cubist. This study was funded in part by an investigator-initiated research grant from Pfizer, Inc (IIR GA5951BG). The funders will not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MLS JPF ADH JKJ JCM KAT GS EP. Performed the experiments: MLS. Analyzed the data: MLS MS. Contributed reagents/materials/analysis tools: JKJ EP. Wrote the paper: MLS JPF ADH JKJ MS JCM KAT GS EP.