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Research Article

Paradoxical Role of Prion Protein Aggregates in Redox-Iron Induced Toxicity

  • Dola Das,

    Affiliation: Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America

    X
  • Xiu Luo,

    Affiliation: Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America

    X
  • Ajay Singh mail,

    neena.singh@case.edu (NS); ajay.singh2@case.edu (AS)

    Affiliation: Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America

    X
  • Yaping Gu,

    Affiliation: Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America

    X
  • Soumya Ghosh,

    Affiliation: Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America

    X
  • Chinmay K. Mukhopadhyay,

    Affiliation: Special Center for Molecular Medicine, Jawaharlal Nehru University, New Delhi, India

    X
  • Shu G. Chen,

    Affiliation: Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America

    X
  • Man-Sun Sy,

    Affiliation: Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America

    X
  • Qingzhong Kong,

    Affiliation: Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America

    X
  • Neena Singh mail

    neena.singh@case.edu (NS); ajay.singh2@case.edu (AS)

    Affiliation: Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America

    X
  • Published: July 06, 2010
  • DOI: 10.1371/journal.pone.0011420

About the Authors

Dola Das, Xiu Luo, Ajay Singh, Yaping Gu, Soumya Ghosh, Shu G. Chen, Man-Sun Sy, Qingzhong Kong, Neena Singh
Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America
Chinmay K. Mukhopadhyay
Special Center for Molecular Medicine, Jawaharlal Nehru University, New Delhi, India

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NS. Performed the experiments: DD XL AS YG SG. Analyzed the data: DD AS NS. Wrote the paper: DD AS NS. Provided helpful critique and comments: CKM. Provided helpful comments: SC MSS. Read the manuscript critically and provided helpful comments: QK.