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Research Article

Valproate Administered after Traumatic Brain Injury Provides Neuroprotection and Improves Cognitive Function in Rats

  • Pramod K. Dash mail,

    P.Dash@uth.tmc.edu

    Affiliation: Departments of Neurobiology and Anatomy, and Neurosurgery, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

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  • Sara A. Orsi,

    Affiliation: Departments of Neurobiology and Anatomy, and Neurosurgery, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

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  • Min Zhang,

    Affiliation: Departments of Neurobiology and Anatomy, and Neurosurgery, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

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  • Raymond J. Grill,

    Affiliation: Department of Integrated Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

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  • Shibani Pati,

    Affiliation: Center for Translation Injury Research, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

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  • Jing Zhao,

    Affiliation: Departments of Neurobiology and Anatomy, and Neurosurgery, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

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  • Anthony N. Moore

    Affiliation: Departments of Neurobiology and Anatomy, and Neurosurgery, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

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  • Published: June 30, 2010
  • DOI: 10.1371/journal.pone.0011383

About the Authors

Pramod K. Dash, Sara A. Orsi, Min Zhang, Jing Zhao, Anthony N. Moore
Departments of Neurobiology and Anatomy, and Neurosurgery, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America
Raymond J. Grill
Department of Integrated Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America
Shibani Pati
Center for Translation Injury Research, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

Corresponding Author

Email: P.Dash@uth.tmc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PD SAO SP AM. Performed the experiments: SAO MZ RJG JZ AM. Analyzed the data: PD SAO MZ JZ AM. Wrote the paper: PD SAO MZ RJG SP JZ AM.