Advertisement
Research Article

Impact of Hydrodynamic Injection and phiC31 Integrase on Tumor Latency in a Mouse Model of MYC-Induced Hepatocellular Carcinoma

  • Lauren E. Woodard,

    Affiliation: Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America

    X
  • Annahita Keravala,

    Affiliation: Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America

    X
  • W. Edward Jung,

    Affiliation: Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America

    X
  • Orly L. Wapinski,

    Affiliation: Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America

    X
  • Qiwei Yang,

    Affiliation: Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California, United States of America

    X
  • Dean W. Felsher,

    Affiliation: Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California, United States of America

    X
  • Michele P. Calos mail

    calos@stanford.edu

    Affiliation: Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America

    X
  • Published: June 29, 2010
  • DOI: 10.1371/journal.pone.0011367

About the Authors

Lauren E. Woodard, Annahita Keravala, W. Edward Jung, Orly L. Wapinski, Michele P. Calos
Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America
Qiwei Yang, Dean W. Felsher
Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California, United States of America

Corresponding Author

Email: calos@stanford.edu

Competing Interests

Michele Calos is an inventor on Stanford-owned patents covering phiC31 integrase and co-founder of Poetic Genetics, a company that has licensed the use of phiC31 integrase for gene therapy purposes. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: LEW AK DWF MPC. Performed the experiments: LEW AK WEJ OLW QY. Analyzed the data: LEW. Contributed reagents/materials/analysis tools: DWF. Wrote the paper: LEW MPC.