About the Authors

Nelson S. Yew

nelson.yew@genzyme.com

Affiliation Genzyme Corporation, Framingham, Massachusetts, United States of America

Hongmei Zhao

Affiliation Genzyme Corporation, Framingham, Massachusetts, United States of America

Eun-Gyoung Hong

Affiliations Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Endocrinology and Medicine, Hallym University College of Medicine, Seoul, South Korea

I-Huan Wu

Affiliation Genzyme Corporation, Framingham, Massachusetts, United States of America

Malgorzata Przybylska

Affiliation Genzyme Corporation, Framingham, Massachusetts, United States of America

Craig Siegel

Affiliation Genzyme Corporation, Framingham, Massachusetts, United States of America

James A. Shayman

Affiliation Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

Cynthia M. Arbeeny

Affiliation Genzyme Corporation, Framingham, Massachusetts, United States of America

Jason K. Kim

Affiliations Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Canwen Jiang

Affiliation Genzyme Corporation, Framingham, Massachusetts, United States of America

Seng H. Cheng

Affiliation Genzyme Corporation, Framingham, Massachusetts, United States of America

Competing Interests

N. Yew, H. Zhao, I.-H. Wu, M. Przybylska, C. Siegel, C. Arbeeny, C. Jiang, and S. Cheng are employees of the Genzyme Corporation. While these authors are employed by Genzyme, it does not alter their adherance to all of the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: NY HZ CA SHC. Performed the experiments: HZ EGH IHW MP. Analyzed the data: NY HZ JK CJ. Contributed reagents/materials/analysis tools: CS JAS. Wrote the paper: NY.