Identification of Conserved Regions and Residues within Hedgehog Acyltransferase Critical for Palmitoylation of Sonic Hedgehog

John A. Buglino; Marilyn D. Resh

doi:10.1371/journal.pone.0011195

Loading metrics

Open Access

Peer-reviewed

Research Article

Identification of Conserved Regions and Residues within Hedgehog Acyltransferase Critical for Palmitoylation of Sonic Hedgehog

John A. Buglino,

Affiliations Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America, Graduate Program in Biochemistry, Cell and Molecular Biology, Weill Graduate School of Medical Sciences, Cornell University, New York, New York, United States of America
⨯
Marilyn D. Resh

* E-mail: m-resh@ski.mskcc.org

Affiliations Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America, Graduate Program in Biochemistry, Cell and Molecular Biology, Weill Graduate School of Medical Sciences, Cornell University, New York, New York, United States of America
⨯

Identification of Conserved Regions and Residues within Hedgehog Acyltransferase Critical for Palmitoylation of Sonic Hedgehog

John A. Buglino,
Marilyn D. Resh

Published: June 23, 2010
https://doi.org/10.1371/journal.pone.0011195

About the Authors

John A. Buglino

Affiliations Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America, Graduate Program in Biochemistry, Cell and Molecular Biology, Weill Graduate School of Medical Sciences, Cornell University, New York, New York, United States of America

Marilyn D. Resh

* E-mail: m-resh@ski.mskcc.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JAB MDR. Performed the experiments: JAB. Analyzed the data: JAB MDR. Wrote the paper: JAB MDR.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Palmitoylation
Is the Subject Area "Palmitoylation" applicable to this article?

Thanks for your feedback.
Hedgehog signaling
Is the Subject Area "Hedgehog signaling" applicable to this article?

Thanks for your feedback.
Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.
Catalysis
Is the Subject Area "Catalysis" applicable to this article?

Thanks for your feedback.
Deletion mutagenesis
Is the Subject Area "Deletion mutagenesis" applicable to this article?

Thanks for your feedback.
Immunoprecipitation
Is the Subject Area "Immunoprecipitation" applicable to this article?

Thanks for your feedback.
Protein synthesis
Is the Subject Area "Protein synthesis" applicable to this article?

Thanks for your feedback.
Mutagenesis
Is the Subject Area "Mutagenesis" applicable to this article?

Thanks for your feedback.