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Research Article

Rapamycin Pharmacokinetic and Pharmacodynamic Relationships in Osteosarcoma: A Comparative Oncology Study in Dogs

  • Melissa C. Paoloni,

    Affiliation: Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America

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  • Christina Mazcko,

    Affiliation: Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America

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  • Elizabeth Fox,

    Affiliation: Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

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  • Timothy Fan,

    Affiliation: University of Illinois, Urbana, Illinois, United States of America

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  • Susan Lana,

    Affiliation: Colorado State University, Fort Collins, Colorado, United States of America

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  • William Kisseberth,

    Affiliation: Ohio State University, Columbus, Ohio, United States of America

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  • David M. Vail,

    Affiliation: University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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  • Kaylee Nuckolls,

    Affiliation: Tumor Metastasis and Biology Section, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America

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  • Tanasa Osborne,

    Affiliation: Tumor Metastasis and Biology Section, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America

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  • Samuel Yalkowsy,

    Affiliation: University of Arizona College of Pharmacy, Tucson, Arizona, United States of America

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  • Daniel Gustafson,

    Affiliation: Colorado State University, Fort Collins, Colorado, United States of America

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  • Yunkai Yu,

    Affiliation: Molecular Targets Core, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America

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  • Liang Cao,

    Affiliation: Molecular Targets Core, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America

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  • Chand Khanna mail

    khannac@mail.nih.gov

    Affiliations: Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America, Tumor Metastasis and Biology Section, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America

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  • Published: June 08, 2010
  • DOI: 10.1371/journal.pone.0011013

About the Authors

Melissa C. Paoloni, Christina Mazcko, Chand Khanna
Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
Elizabeth Fox
Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
Timothy Fan
University of Illinois, Urbana, Illinois, United States of America
Susan Lana, Daniel Gustafson
Colorado State University, Fort Collins, Colorado, United States of America
William Kisseberth
Ohio State University, Columbus, Ohio, United States of America
David M. Vail
University of Wisconsin-Madison, Madison, Wisconsin, United States of America
Kaylee Nuckolls, Tanasa Osborne, Chand Khanna
Tumor Metastasis and Biology Section, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
Samuel Yalkowsy
University of Arizona College of Pharmacy, Tucson, Arizona, United States of America
Yunkai Yu, Liang Cao
Molecular Targets Core, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America

Corresponding Author

Email: khannac@mail.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MP CK. Performed the experiments: MP CM EF TF SL WK DV KN SY DG LC YY. Analyzed the data: MP TO SY DG LC CK. Contributed reagents/materials/analysis tools: MP CM EF TF SL WK DV TO SY DG LC YY. Wrote the paper: MP EF TF SL WK DV LC CK.