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Research Article

Lowering β-Amyloid Levels Rescues Learning and Memory in a Down Syndrome Mouse Model

  • William J. Netzer equal contributor mail,

    equal contributor Contributed equally to this work with: William J. Netzer, Craig Powell

    netzerw@rockefeller.edu

    Affiliation: Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York, United States of America

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  • Craig Powell equal contributor,

    equal contributor Contributed equally to this work with: William J. Netzer, Craig Powell

    Affiliation: Departments of Neurology and Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

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  • Yi Nong,

    Affiliation: Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York, United States of America

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  • Jacqueline Blundell,

    Affiliation: Departments of Neurology and Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

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  • Lili Wong,

    Affiliation: Department of Psychiatry, Columbia University Medical Center, New York, New York, United States of America

    X
  • Karen Duff,

    Affiliation: Department of Psychiatry, Columbia University Medical Center, New York, New York, United States of America

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  • Marc Flajolet,

    Affiliation: Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York, United States of America

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  • Paul Greengard

    Affiliation: Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York, United States of America

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  • Published: June 03, 2010
  • DOI: 10.1371/journal.pone.0010943

About the Authors

William J. Netzer, Yi Nong, Marc Flajolet, Paul Greengard
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York, United States of America
Craig Powell, Jacqueline Blundell
Departments of Neurology and Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America
Lili Wong, Karen Duff
Department of Psychiatry, Columbia University Medical Center, New York, New York, United States of America

Corresponding Author

Email: netzerw@rockefeller.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WJN PG. Performed the experiments: WJN CP JB LW KD. Analyzed the data: WJN CP KD. Contributed reagents/materials/analysis tools: WJN CP YN KD. Wrote the paper: WJN. Contributed to the writing of the paper: CP YN PG. Contributed to the design and writing of the paper: MF.