About the Authors
- David M. Lucas
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Affiliations Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America, College of Pharmacy, The Ohio State University, Columbus, Ohio, United States of America
- Lapo Alinari
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Affiliation Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America
- Derek A. West
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Affiliation Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America
- Melanie E. Davis
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Affiliation Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America
- Ryan B. Edwards
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Affiliation Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America
- Amy J. Johnson
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Affiliation Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America
- Kristie A. Blum
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Affiliation Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America
- Craig C. Hofmeister
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Affiliation Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America
- Michael A. Freitas
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Affiliation Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, Ohio, United States of America
- Mark R. Parthun
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Affiliation Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, Ohio, United States of America
- Dasheng Wang
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Affiliation College of Pharmacy, The Ohio State University, Columbus, Ohio, United States of America
- Amy Lehman
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Affiliation Center for Biostatisics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America
- Xiaoli Zhang
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Affiliation Center for Biostatisics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America
- David Jarjoura
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Affiliation Center for Biostatisics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America
- Samuel K. Kulp
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Affiliation College of Pharmacy, The Ohio State University, Columbus, Ohio, United States of America
- Carlo M. Croce
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Affiliation Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, Ohio, United States of America
- Michael R. Grever
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Affiliations Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America, College of Pharmacy, The Ohio State University, Columbus, Ohio, United States of America
- Ching-Shih Chen
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Affiliation College of Pharmacy, The Ohio State University, Columbus, Ohio, United States of America
- Robert A. Baiocchi
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Contributed equally to this work with: Robert A. Baiocchi, John C. Byrd
Affiliation Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America
- John C. Byrd
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Contributed equally to this work with: Robert A. Baiocchi, John C. Byrd
* E-mail: john.byrd@osumc.edu
Affiliations Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America, College of Pharmacy, The Ohio State University, Columbus, Ohio, United States of America
Competing Interests
MRG served as a consultant to Arno Therapeutics. CSC received royalty payments from Arno Therapeutics per the licensing agreement of AR-42 between The Ohio State University Research Foundation and the company. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: DML LA DAW RAB JCB. Performed the experiments: LA DAW MED RBE. Analyzed the data: DML LA DAW MED RBE AJJ KAB CCH MAF MRP AL XZ DJ MRG RAB JCB. Contributed reagents/materials/analysis tools: LA AJJ KAB CCH MAF MRP DW SKK CC MRG CSC. Wrote the paper: DML LA DAW RAB JCB.