About the Authors

David M. Lucas

Affiliations Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America, College of Pharmacy, The Ohio State University, Columbus, Ohio, United States of America

Lapo Alinari

Affiliation Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America

Derek A. West

Affiliation Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America

Melanie E. Davis

Affiliation Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America

Ryan B. Edwards

Affiliation Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America

Amy J. Johnson

Affiliation Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America

Kristie A. Blum

Affiliation Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America

Craig C. Hofmeister

Affiliation Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America

Michael A. Freitas

Affiliation Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, Ohio, United States of America

Mark R. Parthun

Affiliation Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, Ohio, United States of America

Dasheng Wang

Affiliation College of Pharmacy, The Ohio State University, Columbus, Ohio, United States of America

Amy Lehman

Affiliation Center for Biostatisics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America

Xiaoli Zhang

Affiliation Center for Biostatisics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America

David Jarjoura

Affiliation Center for Biostatisics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America

Samuel K. Kulp

Affiliation College of Pharmacy, The Ohio State University, Columbus, Ohio, United States of America

Carlo M. Croce

Affiliation Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, Ohio, United States of America

Michael R. Grever

Affiliations Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America, College of Pharmacy, The Ohio State University, Columbus, Ohio, United States of America

Ching-Shih Chen

Affiliation College of Pharmacy, The Ohio State University, Columbus, Ohio, United States of America

Robert A. Baiocchi

Contributed equally to this work with: Robert A. Baiocchi, John C. Byrd

Affiliation Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America

John C. Byrd

Contributed equally to this work with: Robert A. Baiocchi, John C. Byrd

john.byrd@osumc.edu

Affiliations Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America, College of Pharmacy, The Ohio State University, Columbus, Ohio, United States of America

Competing Interests

MRG served as a consultant to Arno Therapeutics. CSC received royalty payments from Arno Therapeutics per the licensing agreement of AR-42 between The Ohio State University Research Foundation and the company. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: DML LA DAW RAB JCB. Performed the experiments: LA DAW MED RBE. Analyzed the data: DML LA DAW MED RBE AJJ KAB CCH MAF MRP AL XZ DJ MRG RAB JCB. Contributed reagents/materials/analysis tools: LA AJJ KAB CCH MAF MRP DW SKK CC MRG CSC. Wrote the paper: DML LA DAW RAB JCB.