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Research Article

Release of Membrane-Bound Vesicles and Inhibition of Tumor Cell Adhesion by the Peptide Neopetrosiamide A

  • Pamela Austin,

    Affiliations: Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada, Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada

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  • Markus Heller,

    Affiliation: Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada

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  • David E. Williams,

    Affiliations: Department of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada, Department of Earth and Ocean Sciences, University of British Columbia, Vancouver, British Columbia, Canada

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  • Lawrence P. McIntosh,

    Affiliations: Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada, Department of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada

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  • A. Wayne Vogl,

    Affiliation: Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada

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  • Leonard J. Foster,

    Affiliation: Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada

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  • Raymond J. Andersen,

    Affiliations: Department of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada, Department of Earth and Ocean Sciences, University of British Columbia, Vancouver, British Columbia, Canada

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  • Michel Roberge,

    Affiliation: Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada

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  • Calvin D. Roskelley mail

    roskelly@interchange.ubc.ca

    Affiliations: Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada, The Program in Breast Cancer Metastasis, University of British Columbia, Vancouver, British Columbia, Canada

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  • Published: May 26, 2010
  • DOI: 10.1371/journal.pone.0010836

About the Authors

Pamela Austin, A. Wayne Vogl, Calvin D. Roskelley
Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada
Pamela Austin, Markus Heller, Lawrence P. McIntosh, Leonard J. Foster, Michel Roberge
Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada
David E. Williams, Lawrence P. McIntosh, Raymond J. Andersen
Department of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada
David E. Williams, Raymond J. Andersen
Department of Earth and Ocean Sciences, University of British Columbia, Vancouver, British Columbia, Canada
Calvin D. Roskelley
The Program in Breast Cancer Metastasis, University of British Columbia, Vancouver, British Columbia, Canada

Corresponding Author

Email: roskelly@interchange.ubc.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PA MH DEW LPM AWV LJF RJA MR CDR. Performed the experiments: PA MH DEW AWV LJF. Analyzed the data: PA MH DEW LPM AWV LJF RJA MR CDR. Contributed reagents/materials/analysis tools: MH DEW RJA. Wrote the paper: PA MR CDR.