About the Authors

Nidhi Gupta

Contributed equally to this work with: Nidhi Gupta, Niels Fisker

Affiliation Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada

Niels Fisker

Contributed equally to this work with: Nidhi Gupta, Niels Fisker

Affiliation Santaris Pharma A/S, Hørsholm, Denmark

Marie-Claude Asselin

Affiliation Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada

Marie Lindholm

Affiliation Santaris Pharma A/S, Hørsholm, Denmark

Christoph Rosenbohm

Affiliation Santaris Pharma A/S, Hørsholm, Denmark

Henrik Ørum

Affiliation Santaris Pharma A/S, Hørsholm, Denmark

Joacim Elmén

Affiliation Santaris Pharma A/S, Hørsholm, Denmark

Nabil G. Seidah

seidahn@ircm.qc.ca

These authors also contributed equally to this work.

Affiliation Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada

Ellen Marie Straarup

These authors also contributed equally to this work.

Affiliation Santaris Pharma A/S, Hørsholm, Denmark

Competing Interests

NGS, NG and M-CA are employees of the IRCM. NF, ML, CR, JE and EMS are employees of Santaris Pharmna A/S. This does not alter their adherence to all the PLOS ONE policies, including sharing data and materials.

Author Contributions

Conceived and designed the experiments: NG NF JE NGS EMS. Performed the experiments: NG NF MCA ML HØ. Analyzed the data: NG NF ML CR JE NGS EMS. Contributed reagents/materials/analysis tools: NG CR HØ EMS. Wrote the paper: NG NF JE NGS EMS.