About the Authors
- Lindsay M. Edwards
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* E-mail: L.M.Edwards@utas.edu.au
Current address: Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia
Affiliations Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, Oxfordshire, United Kingdom, The Oxford Centre for Clinical Magnetic Resonance Research, John Radcliffe Hospital, Oxford, Oxfordshire, United Kingdom
- Andrew J. Murray
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Current address: Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom
Affiliation Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, Oxfordshire, United Kingdom
- Damian J. Tyler
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Affiliations Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, Oxfordshire, United Kingdom, The Oxford Centre for Clinical Magnetic Resonance Research, John Radcliffe Hospital, Oxford, Oxfordshire, United Kingdom
- Graham J. Kemp
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Affiliation School of Clinical Sciences, University of Liverpool, Liverpool, Merseyside, United Kingdom
- Cameron J. Holloway
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Affiliation The Oxford Centre for Clinical Magnetic Resonance Research, John Radcliffe Hospital, Oxford, Oxfordshire, United Kingdom
- Peter A. Robbins
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Affiliation Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, Oxfordshire, United Kingdom
- Stefan Neubauer
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Affiliation The Oxford Centre for Clinical Magnetic Resonance Research, John Radcliffe Hospital, Oxford, Oxfordshire, United Kingdom
- Denny Levett
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Affiliation Centre for Altitude, Space, and Extreme Environment Medicine, University College London, London, United Kingdom
- Hugh E. Montgomery
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Affiliations Centre for Altitude, Space, and Extreme Environment Medicine, University College London, London, United Kingdom, Institute for Human Health and Performance, University College London, London, United Kingdom
- Mike P. Grocott
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Affiliation Centre for Altitude, Space, and Extreme Environment Medicine, University College London, London, United Kingdom
- Kieran Clarke
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Affiliation Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, Oxfordshire, United Kingdom
- Caudwell Xtreme Everest Research Group
Competing Interests
This project was partly funded by grants from BOC Medical (now Linde Gas Therapeutics), Lilly Critical Care, The London Clinic, Smiths Medical, Deltex Medical and The Rolex Foundation. All monies were given as unrestricted grants: the funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. This does not alter the authors' adherence to any of the PLoS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: LME AJM DT GJK CJH DL HEM MPWG KC. Performed the experiments: LME AJM CJH DL MPWG. Analyzed the data: LME GJK CJH KC. Wrote the paper: LME AJM DT GJK CJH PAR SN DL HEM MPWG KC.