About the Authors

Juliet A. Moncaster

Contributed equally to this work with: Juliet A. Moncaster, Roberto Pineda, Robert D. Moir

Affiliation Molecular Aging & Development Laboratory, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Roberto Pineda

Contributed equally to this work with: Juliet A. Moncaster, Roberto Pineda, Robert D. Moir

Affiliation Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, United States of America

Robert D. Moir

Contributed equally to this work with: Juliet A. Moncaster, Roberto Pineda, Robert D. Moir

Affiliation Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America

Suqian Lu

Affiliation Molecular Aging & Development Laboratory, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Mark A. Burton

Affiliation Molecular Aging & Development Laboratory, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Joy G. Ghosh

Affiliation Molecular Aging & Development Laboratory, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Maria Ericsson

Affiliation Electron Microscopy Facility, Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Stephanie J. Soscia

Affiliation Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America

Anca Mocofanescu

Affiliation Molecular Aging & Development Laboratory, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Rebecca D. Folkerth

Affiliation Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Richard M. Robb

Affiliation Department of Ophthalmology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America

Jer R. Kuszak

Affiliation Departments of Ophthalmology and Pathology, Rush University Medical Center, Chicago, Illinois, United States of America

John I. Clark

Affiliation Departments of Biological Structure and Ophthalmology, University of Washington, Seattle, Washington, United States of America

Rudolph E. Tanzi

Affiliation Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America

David G. Hunter

Affiliation Department of Ophthalmology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America

Lee E. Goldstein

LGOLD@BU.EDU

Affiliation Molecular Aging & Development Laboratory, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Competing Interests

Authors Moncaster, Pineda, Lu, Burton, Ghosh, Ericsson, Soscia, Mocofanescu, Folkerth, Robb, Kuszak, Clark, and Hunter report no conflict of interest. The following authors reported consultant activity during the course of this study: Drs. Tanzi and Goldstein, Neuroptix Corp, Acton, MA; Drs. Moir, Tanzi, and Goldstein, Covance, Dedham, MA. No financial support was provided by any commercial entity for this study.

Author Contributions

Conceived and designed the experiments: JAM RP RDM RMR JIC RET DGH LEG. Performed the experiments: JAM RDM SL MAB JGG ME SJS AM. Analyzed the data: JAM RP RDM MAB ME JK JIC RET DGH LEG. Contributed reagents/materials/analysis tools: JAM RP RDM SL MAB ME RF RMR JK RET DGH LEG. Wrote the paper: JAM RP RDM DGH LEG. Revised the manuscript: JGG AM RF RMR JK JIC RET.