Sensitivity of Noninvasive Prenatal Detection of Fetal Aneuploidy from Maternal Plasma Using Shotgun Sequencing Is Limited Only by Counting Statistics

H. Christina Fan; Stephen R. Quake

doi:10.1371/journal.pone.0010439

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Open Access

Peer-reviewed

Research Article

Sensitivity of Noninvasive Prenatal Detection of Fetal Aneuploidy from Maternal Plasma Using Shotgun Sequencing Is Limited Only by Counting Statistics

H. Christina Fan,

Affiliation Department of Bioengineering, Stanford University and Howard Hughes Medical Institute, Stanford, California, United States of America
⨯
Stephen R. Quake

* E-mail: quake@stanford.edu

Affiliation Department of Bioengineering, Stanford University and Howard Hughes Medical Institute, Stanford, California, United States of America
⨯

Sensitivity of Noninvasive Prenatal Detection of Fetal Aneuploidy from Maternal Plasma Using Shotgun Sequencing Is Limited Only by Counting Statistics

H. Christina Fan,
Stephen R. Quake

Published: May 3, 2010
https://doi.org/10.1371/journal.pone.0010439

About the Authors

H. Christina Fan

Affiliation Department of Bioengineering, Stanford University and Howard Hughes Medical Institute, Stanford, California, United States of America

Stephen R. Quake

* E-mail: quake@stanford.edu

Affiliation Department of Bioengineering, Stanford University and Howard Hughes Medical Institute, Stanford, California, United States of America

Competing Interests

Stephen Quake is a founder and consultant of Fluidigm Corporation and Helicos Biosciences Corporation, and a consultant of Artemis Health. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Analyzed the data: HCF SRQ. Wrote the paper: HCF SRQ.

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Shotgun sequencing
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Aneuploidy
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DNA sequencing
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X chromosomes
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Pregnancy
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Y chromosomes
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Down syndrome
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High throughput sequencing
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