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Research Article

Expression of the Rap1 Guanine Nucleotide Exchange Factor, MR-GEF, Is Altered in Individuals with Bipolar Disorder

  • Angela Bithell,

    Affiliation: Department of Psychological Medicine, Institute of Psychiatry, King's College London, London, United Kingdom

    Current address: Centre for the Cellular Basis of behaviour, The James Black Centre, Institute of Psychiatry, King's College London, London, United Kingdom

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  • Tony Hsu equal contributor,

    equal contributor Contributed equally to this work with: Tony Hsu, Apsara Kandanearatchi

    Affiliation: Center for Behavioral Genomics, Department of Psychiatry, University of California San Diego, San Diego, California, United States of America

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  • Apsara Kandanearatchi equal contributor,

    equal contributor Contributed equally to this work with: Tony Hsu, Apsara Kandanearatchi

    Affiliation: Department of Psychological Medicine, Institute of Psychiatry, King's College London, London, United Kingdom

    Current address: Centre for Immunology, St Vincent's Hospital/University of New South Wales, Sydney, New South Wales, Australia

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  • Sabine Landau,

    Affiliation: Department of Biostatistics and Computing, Institute of Psychiatry, King's College London, London, United Kingdom

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  • Ian P. Everall,

    Affiliations: Department of Psychological Medicine, Institute of Psychiatry, King's College London, London, United Kingdom, Center for Behavioral Genomics, Department of Psychiatry, University of California San Diego, San Diego, California, United States of America

    Current address: Department of Psychiatry, The University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria, Australia

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  • Ming T. Tsuang,

    Affiliation: Center for Behavioral Genomics, Department of Psychiatry, University of California San Diego, San Diego, California, United States of America

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  • Gursharan Chana,

    Affiliations: Department of Psychological Medicine, Institute of Psychiatry, King's College London, London, United Kingdom, Center for Behavioral Genomics, Department of Psychiatry, University of California San Diego, San Diego, California, United States of America

    Current address: Department of Psychiatry, The University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria, Australia

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  • Brenda P. Williams mail

    brenda.p.williams@kcl.ac.uk

    Affiliation: Department of Psychological Medicine, Institute of Psychiatry, King's College London, London, United Kingdom

    Current address: Centre for the Cellular Basis of behaviour, The James Black Centre, Institute of Psychiatry, King's College London, London, United Kingdom

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  • Published: April 28, 2010
  • DOI: 10.1371/journal.pone.0010392

About the Authors

Angela Bithell, Apsara Kandanearatchi, Ian P. Everall, Gursharan Chana, Brenda P. Williams
Department of Psychological Medicine, Institute of Psychiatry, King's College London, London, United Kingdom
Tony Hsu, Ian P. Everall, Ming T. Tsuang, Gursharan Chana
Center for Behavioral Genomics, Department of Psychiatry, University of California San Diego, San Diego, California, United States of America
Sabine Landau
Department of Biostatistics and Computing, Institute of Psychiatry, King's College London, London, United Kingdom

Corresponding Author

Email: brenda.p.williams@kcl.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: IPE BPW. Performed the experiments: AB AK. Analyzed the data: AB TH AK SL GC. Contributed reagents/materials/analysis tools: IPE MT BPW. Wrote the paper: BPW. Interpreted data: BPW AB SL IPE GC. Revised manuscript: AB SL IPE GC. Approved final version: AB TH AK SL IPE GC. Provided research support staff: MT.