MAPk Activation Modulates Permeability of Isolated Rat Alveolar Epithelial Cell Monolayers Following Cyclic Stretch

Taylor S. Cohen; Gladys Gray Lawrence; Amit Khasgiwala; Susan S. Margulies

doi:10.1371/journal.pone.0010385

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Open Access

Peer-reviewed

Research Article

MAPk Activation Modulates Permeability of Isolated Rat Alveolar Epithelial Cell Monolayers Following Cyclic Stretch

Taylor S. Cohen,

Affiliation Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Gladys Gray Lawrence,

Affiliation Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Amit Khasgiwala,

Affiliation Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Susan S. Margulies

* E-mail: margulies@seas.upenn.edu

Affiliation Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯

MAPk Activation Modulates Permeability of Isolated Rat Alveolar Epithelial Cell Monolayers Following Cyclic Stretch

Taylor S. Cohen,
Gladys Gray Lawrence,
Amit Khasgiwala,
Susan S. Margulies

Published: April 28, 2010
https://doi.org/10.1371/journal.pone.0010385

About the Authors

Taylor S. Cohen

Affiliation Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Gladys Gray Lawrence

Affiliation Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Amit Khasgiwala

Affiliation Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Susan S. Margulies

* E-mail: margulies@seas.upenn.edu

Affiliation Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TSC SSM. Performed the experiments: TSC GGL AK. Analyzed the data: TSC GGL. Contributed reagents/materials/analysis tools: SSM. Wrote the paper: TSC SSM.

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Permeability
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Phosphorylation
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ERK signaling cascade
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MAPK signaling cascades
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Tight junctions
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Epithelial cells
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Signal inhibition
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Protein kinase signaling cascade
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