About the Authors
- Elena Favaro
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Contributed equally to this work with: Elena Favaro, Anassuya Ramachandran
Affiliations Genomics Group, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
- Anassuya Ramachandran
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Contributed equally to this work with: Elena Favaro, Anassuya Ramachandran
Affiliation Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
- Robert McCormick
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Affiliation Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
- Harriet Gee
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Affiliation Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
- Christine Blancher
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Affiliation Genomics Group, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
- Meredith Crosby
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Affiliation Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut, United States of America
- Cecilia Devlin
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Affiliation Indiana University, Indianapolis, Indiana, United States of America
- Christopher Blick
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Affiliation Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
- Francesca Buffa
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Affiliation Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
- Ji-Liang Li
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Affiliation Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
- Borivoj Vojnovic
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Affiliation Gray Institute for Radiation Oncology & Biology, University of Oxford, Oxford, United Kingdom
- Ricardo Pires das Neves
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Affiliation Molecular Haematology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
- Peter Glazer
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Affiliation Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut, United States of America
- Francisco Iborra
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Affiliation Molecular Haematology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
- Mircea Ivan
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* E-mail: mivan@iupui.edu (MI); aharris.lab@imm.ox.ac.uk (ALH)
Affiliation Indiana University, Indianapolis, Indiana, United States of America
- Jiannis Ragoussis
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¶These authors also contributed equally to this work.
Affiliation Genomics Group, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
- Adrian L. Harris
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* E-mail: mivan@iupui.edu (MI); aharris.lab@imm.ox.ac.uk (ALH)
¶These authors also contributed equally to this work.
Affiliation Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
Competing Interests
The authors have declared that no competing interests exist.
Author Contributions
Wrote the paper: ALH. Project Director, initial suggestion of target: ALH. Analysis of mRNA changes in hypoxia, ISCU protein changes, enzyme assays: EF AR. Analysis of ISCU RNA and protein, mitochondrial fractionation: RM. Analysis of a panel of cell lines and xenografts: HG. Analysis of the 3′ UTR: C Blancher. Analysis of clonogenic survival: MC CD. Analysis of iron metabolism: C Blick. Bioinformatics analysis of the databases: FMB. Xenograft studies: JLL. Analysis of data, discussion: BV PG. Analysis of free radicals: RPdN. Analysis of free radical production: FJI. Analysis of target, discussion of targets, cell survival assays: MI. Bioinformatics array analysis, discussion: JR.