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Research Article

Characterization of Quasispecies of Pandemic 2009 Influenza A Virus (A/H1N1/2009) by De Novo Sequencing Using a Next-Generation DNA Sequencer

  • Makoto Kuroda mail,

    makokuro@nih.go.jp

    Affiliation: Laboratory of Bacterial Genomics, Pathogen Genomics Center, National Institute of Infectious Diseases, Tokyo, Japan

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  • Harutaka Katano,

    Affiliation: Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan

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  • Noriko Nakajima,

    Affiliation: Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan

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  • Minoru Tobiume,

    Affiliation: Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan

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  • Akira Ainai,

    Affiliation: Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan

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  • Tsuyoshi Sekizuka,

    Affiliation: Laboratory of Bacterial Genomics, Pathogen Genomics Center, National Institute of Infectious Diseases, Tokyo, Japan

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  • Hideki Hasegawa,

    Affiliation: Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan

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  • Masato Tashiro,

    Affiliation: Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan

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  • Yuko Sasaki,

    Affiliation: Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, Tokyo, Japan

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  • Yoshichika Arakawa,

    Affiliation: Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, Tokyo, Japan

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  • Satoru Hata,

    Affiliation: Department of Clinical Laboratory, Nagano Red Cross Hospital, Nagano, Japan

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  • Masahide Watanabe,

    Affiliation: Department of Pathology, Nagano Red Cross Hospital, Nagano, Japan

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  • Tetsutaro Sata

    Affiliation: Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan

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  • Published: April 23, 2010
  • DOI: 10.1371/journal.pone.0010256

About the Authors

Makoto Kuroda, Tsuyoshi Sekizuka
Laboratory of Bacterial Genomics, Pathogen Genomics Center, National Institute of Infectious Diseases, Tokyo, Japan
Harutaka Katano, Noriko Nakajima, Minoru Tobiume, Akira Ainai, Tetsutaro Sata
Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
Hideki Hasegawa, Masato Tashiro
Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan
Yuko Sasaki, Yoshichika Arakawa
Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, Tokyo, Japan
Satoru Hata
Department of Clinical Laboratory, Nagano Red Cross Hospital, Nagano, Japan
Masahide Watanabe
Department of Pathology, Nagano Red Cross Hospital, Nagano, Japan

Corresponding Author

Email: makokuro@nih.go.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MK TS. Performed the experiments: MK HK TS YS. Analyzed the data: MK HK TS HH. Contributed reagents/materials/analysis tools: HK NN MT AA MT YA SH MW TS. Wrote the paper: MK.