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Research Article

Small Molecules Showing Significant Protection of Mice against Botulinum Neurotoxin Serotype A

  • Yuan-Ping Pang mail,

    pang@mayo.edu (Y-PP for chemistry); charles.b.millard@us.army.mil (CBM for biology)

    Affiliation: Computer-Aided Molecular Design Laboratory, Mayo Clinic, Rochester, Minnesota, United States of America

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  • Jon Davis,

    Affiliation: Division of Biochemistry, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America

    Current address: Integrated Toxicology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, United States of America

    X
  • Shaohua Wang,

    Affiliation: Computer-Aided Molecular Design Laboratory, Mayo Clinic, Rochester, Minnesota, United States of America

    X
  • Jewn Giew Park,

    Affiliation: Computer-Aided Molecular Design Laboratory, Mayo Clinic, Rochester, Minnesota, United States of America

    X
  • Madhusoodana P. Nambiar,

    Affiliation: Division of Biochemistry, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America

    X
  • James J. Schmidt,

    Affiliation: Integrated Toxicology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, United States of America

    X
  • Charles B. Millard mail

    pang@mayo.edu (Y-PP for chemistry); charles.b.millard@us.army.mil (CBM for biology)

    Affiliation: Division of Biochemistry, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America

    Current address: United States Army Medical Research and Materiel Command, Fort Detrick, Maryland, United States of America

    X
  • Published: April 13, 2010
  • DOI: 10.1371/journal.pone.0010129

About the Authors

Yuan-Ping Pang, Shaohua Wang, Jewn Giew Park
Computer-Aided Molecular Design Laboratory, Mayo Clinic, Rochester, Minnesota, United States of America
Jon Davis, Madhusoodana P. Nambiar, Charles B. Millard
Division of Biochemistry, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America
James J. Schmidt
Integrated Toxicology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, United States of America

Corresponding Authors

Competing Interests

Y-PP, JD, SW, JGP, JJS, and CBM are inventors of a filed provisional patent application titled “Small-Molecule Botulinum Toxin Inhibitors” that covers the inhibitors described in this paper, but this does not alter the adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: Y-PP JD JJS CBM. Design of F4H and F3A: Y-PP SW JGP. Syntheses of F4H, F3A, and H3H: SW. Performed the experiments: Y-PP JD SW JGP MPN JJS. Analyzed the data: Y-PP JD SW JGP MPN JJS CBM. Wrote the paper: Y-PP JD CBM. Contributed with revisions: Y-PP JD SW JGP MPN JJS CBM.