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Research Article

Phosphodiesterase Type 5 Inhibitors Increase Herceptin Transport and Treatment Efficacy in Mouse Metastatic Brain Tumor Models

  • Jinwei Hu equal contributor,

    equal contributor Contributed equally to this work with: Jinwei Hu, Julia Y. Ljubimova

    Affiliation: Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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  • Julia Y. Ljubimova equal contributor mail,

    equal contributor Contributed equally to this work with: Jinwei Hu, Julia Y. Ljubimova

    ljubimovaj@cshs.org

    Affiliation: Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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  • Satoshi Inoue,

    Affiliation: Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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  • Bindu Konda,

    Affiliation: Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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  • Rameshwar Patil,

    Affiliation: Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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  • Hui Ding,

    Affiliation: Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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  • Andres Espinoza,

    Affiliation: Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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  • Kolja A. Wawrowsky,

    Affiliation: Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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  • Chirag Patil,

    Affiliation: Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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  • Alexander V. Ljubimov,

    Affiliations: Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, United States of America

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  • Keith L. Black

    Affiliation: Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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  • Published: April 19, 2010
  • DOI: 10.1371/journal.pone.0010108

About the Authors

Jinwei Hu, Julia Y. Ljubimova, Satoshi Inoue, Bindu Konda, Rameshwar Patil, Hui Ding, Andres Espinoza, Chirag Patil, Keith L. Black
Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
Kolja A. Wawrowsky
Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
Alexander V. Ljubimov
Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
Alexander V. Ljubimov
David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, United States of America

Corresponding Author

Email: ljubimovaj@cshs.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JYL SI AL KLB. Performed the experiments: JH JYL SI BK RP HD AE KW. Analyzed the data: JH JYL RP HD CP AL KLB. Contributed reagents/materials/analysis tools: JH JYL SI RP HD AL. Wrote the paper: JH JYL AL KLB.