About the Authors

Patricia Spilman

Affiliation The Buck Institute for Age Research, Novato, California, United States of America

Natalia Podlutskaya

Affiliations Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, The Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

Matthew J. Hart

Affiliation Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

Jayanta Debnath

Affiliation Department of Pathology, University of California San Francisco, San Francisco, California, United States of America

Olivia Gorostiza

Affiliation The Buck Institute for Age Research, Novato, California, United States of America

Dale Bredesen

Affiliation The Buck Institute for Age Research, Novato, California, United States of America

Arlan Richardson

Affiliations The Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Geriatric Research, Education and Clinical Center and Research Service, South Texas Veterans Health Care System, San Antonio, Texas, United States of America

Randy Strong

Affiliations The Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Geriatric Research, Education and Clinical Center and Research Service, South Texas Veterans Health Care System, San Antonio, Texas, United States of America

Veronica Galvan

galvanv@uthscsa.edu

Affiliations Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, The Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: VG. Performed the experiments: PS NP MJH. Analyzed the data: JD AR RS VG. Contributed reagents/materials/analysis tools: RS. Wrote the paper: VG. Principal investigator of the study: VG. Responsible for the project design: VG. Supervised technical personnel: VG. Interpretation of results: VG. Preparation of the manuscript: VG AR RS. Performance of behavioral experiments: VG, PS. Conducted immunohistochemical experiments: PS. Conducted all biochemical experiments: NP MJH. Key review of the manuscript: MJH JD. Assistance in the analysis of biochemical data: MJH. Interpretation of the autophagy data: JD. General colony maintenance and monitoring: OG. Performed euthanasia, tissues dissection and preparation of PDAPP mice: OG. Provided resources and partial support during treatment and testing of PDAPP mice at the Buck Institute: DEB. Prepared the rapamycin-containing diet and tested it for rapamycin levels: RS.