About the Authors
- Patricia Spilman
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Affiliation The Buck Institute for Age Research, Novato, California, United States of America
- Natalia Podlutskaya
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Affiliations Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, The Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
- Matthew J. Hart
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Affiliation Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
- Jayanta Debnath
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Affiliation Department of Pathology, University of California San Francisco, San Francisco, California, United States of America
- Olivia Gorostiza
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Affiliation The Buck Institute for Age Research, Novato, California, United States of America
- Dale Bredesen
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Affiliation The Buck Institute for Age Research, Novato, California, United States of America
- Arlan Richardson
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Affiliations The Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Geriatric Research, Education and Clinical Center and Research Service, South Texas Veterans Health Care System, San Antonio, Texas, United States of America
- Randy Strong
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Affiliations The Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Geriatric Research, Education and Clinical Center and Research Service, South Texas Veterans Health Care System, San Antonio, Texas, United States of America
- Veronica Galvan
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* E-mail: galvanv@uthscsa.edu
Affiliations Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, The Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
Competing Interests
The authors have declared that no competing interests exist.
Author Contributions
Conceived and designed the experiments: VG. Performed the experiments: PS NP MJH. Analyzed the data: JD AR RS VG. Contributed reagents/materials/analysis tools: RS. Wrote the paper: VG. Principal investigator of the study: VG. Responsible for the project design: VG. Supervised technical personnel: VG. Interpretation of results: VG. Preparation of the manuscript: VG AR RS. Performance of behavioral experiments: VG, PS. Conducted immunohistochemical experiments: PS. Conducted all biochemical experiments: NP MJH. Key review of the manuscript: MJH JD. Assistance in the analysis of biochemical data: MJH. Interpretation of the autophagy data: JD. General colony maintenance and monitoring: OG. Performed euthanasia, tissues dissection and preparation of PDAPP mice: OG. Provided resources and partial support during treatment and testing of PDAPP mice at the Buck Institute: DEB. Prepared the rapamycin-containing diet and tested it for rapamycin levels: RS.