Inference of Functional Relations in Predicted Protein Networks with a Machine Learning Approach

Beatriz García-Jiménez; David Juan; Iakes Ezkurdia; Eduardo Andrés-León; Alfonso Valencia

doi:10.1371/journal.pone.0009969

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Open Access

Peer-reviewed

Research Article

Inference of Functional Relations in Predicted Protein Networks with a Machine Learning Approach

Beatriz García-Jiménez ,

Contributed equally to this work with: Beatriz García-Jiménez, David Juan

Affiliation Computer Science Department, Universidad Carlos III de Madrid, Madrid, Spain
⨯
David Juan ,

Contributed equally to this work with: Beatriz García-Jiménez, David Juan

Affiliation Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre - (CNIO), Madrid, Spain
⨯
Iakes Ezkurdia,

Affiliation Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre - (CNIO), Madrid, Spain
⨯
Eduardo Andrés-León,

Affiliation Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre - (CNIO), Madrid, Spain
⨯
Alfonso Valencia

* E-mail: valencia@cnio.es

Affiliation Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre - (CNIO), Madrid, Spain
⨯

Inference of Functional Relations in Predicted Protein Networks with a Machine Learning Approach

Beatriz García-Jiménez,
David Juan,
Iakes Ezkurdia,
Eduardo Andrés-León,
Alfonso Valencia

Published: April 1, 2010
https://doi.org/10.1371/journal.pone.0009969

About the Authors

Beatriz García-Jiménez

Contributed equally to this work with: Beatriz García-Jiménez, David Juan

Affiliation Computer Science Department, Universidad Carlos III de Madrid, Madrid, Spain

David Juan

Contributed equally to this work with: Beatriz García-Jiménez, David Juan

Affiliation Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre - (CNIO), Madrid, Spain

Iakes Ezkurdia

Affiliation Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre - (CNIO), Madrid, Spain

Eduardo Andrés-León

Affiliation Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre - (CNIO), Madrid, Spain

Alfonso Valencia

* E-mail: valencia@cnio.es

Affiliation Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre - (CNIO), Madrid, Spain

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AV. Performed the experiments: BGJ. Analyzed the data: BGJ DJ IE. Contributed reagents/materials/analysis tools: DJ EAL. Wrote the paper: BGJ DJ IE.

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Machine learning algorithms
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Protein interactions
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Forecasting
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Bacterial genomics
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Gene fusion
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Gene regulation
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Machine learning
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Phylogenetics
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