About the Authors

Alain C. Tissot

Affiliation Cytos Biotechnology AG, Zurich-Schlieren, Switzerland

Regina Renhofa

Affiliation Latvian Biomedical Research and Study Centre, Riga, Latvia

Nicole Schmitz

Affiliation Cytos Biotechnology AG, Zurich-Schlieren, Switzerland

Indulis Cielens

Affiliation Latvian Biomedical Research and Study Centre, Riga, Latvia

Edwin Meijerink

Affiliation Cytos Biotechnology AG, Zurich-Schlieren, Switzerland

Velta Ose

Affiliation Latvian Biomedical Research and Study Centre, Riga, Latvia

Gary T. Jennings

Affiliation Cytos Biotechnology AG, Zurich-Schlieren, Switzerland

Philippe Saudan

Affiliation Cytos Biotechnology AG, Zurich-Schlieren, Switzerland

Paul Pumpens

paul@biomed.lu.lv (PP); martin.bachmann@cytos.com (MFB)

Affiliation Latvian Biomedical Research and Study Centre, Riga, Latvia

Martin F. Bachmann

paul@biomed.lu.lv (PP); martin.bachmann@cytos.com (MFB)

Affiliation Cytos Biotechnology AG, Zurich-Schlieren, Switzerland

Competing Interests

ACT, NS, EM, GTJ, PS and MFB are or were employees of Cytos Biotechnology AG when performing the study, and hold or were holding stocks or stock options of Cytos Biotechnology AG when performing the study. RR, IC, VO and PP received research funding from Cytos Biotechnology AG. Although funding was provided by a commercial source, it does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials, as detailed online in the guide for authors [http://www.plosone.org/static/policies.action#sharing]. A patent was filed based on the outcome of the study: “WO/2006/032674 Virus-Like Particles Comprising a Fusion Protein of the Coat Protein of Ap205 and an Antigenic Polypeptide”.

Author Contributions

Conceived and designed the experiments: ACT RR IC EM VO GTJ PS PP MFB. Performed the experiments: RR IC EM VO. Analyzed the data: ACT RR IC EM GTJ PS MFB. Wrote the paper: ACT PP MFB. Preformed all the work on Influenza Virus: NS.