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Research Article

Epidemiologic Investigation of Immune-Mediated Polyradiculoneuropathy among Abattoir Workers Exposed to Porcine Brain

  • Stacy M. Holzbauer,

    Affiliations: Infectious Disease, Epidemiology, Prevention and Control Division, Minnesota Department of Health, Saint Paul, Minnesota, United States of America, Epidemic Intelligence Service, Office of Workforce and Career Development, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

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  • Aaron S. DeVries mail,

    Aaron.DeVries@state.mn.us

    Affiliation: Infectious Disease, Epidemiology, Prevention and Control Division, Minnesota Department of Health, Saint Paul, Minnesota, United States of America

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  • James J. Sejvar,

    Affiliation: Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector-borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

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  • Christine H. Lees,

    Affiliation: Infectious Disease, Epidemiology, Prevention and Control Division, Minnesota Department of Health, Saint Paul, Minnesota, United States of America

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  • Jennifer Adjemian,

    Affiliation: Epidemic Intelligence Service, Office of Workforce and Career Development, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

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  • Jennifer H. McQuiston,

    Affiliation: Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector-borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

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  • Carlota Medus,

    Affiliation: Infectious Disease, Epidemiology, Prevention and Control Division, Minnesota Department of Health, Saint Paul, Minnesota, United States of America

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  • Catherine A. Lexau,

    Affiliation: Infectious Disease, Epidemiology, Prevention and Control Division, Minnesota Department of Health, Saint Paul, Minnesota, United States of America

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  • Julie R. Harris,

    Affiliation: Epidemic Intelligence Service, Office of Workforce and Career Development, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

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  • Sergio E. Recuenco,

    Affiliation: Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector-borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

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  • Ermias D. Belay,

    Affiliation: Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector-borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

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  • James F. Howell,

    Affiliation: Public Health Preparedness and Emergency Response, Indiana State Department of Health, Indianapolis, Indiana, United States of America

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  • Bryan F. Buss,

    Affiliations: Epidemic Intelligence Service, Office of Workforce and Career Development, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America, Division of Public Health, Nebraska Department of Health and Human Services, Lincoln, Nebraska, United States of America

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  • Mady Hornig,

    Affiliation: Center for Infection and Immunity, Columbia University, New York, New York, United States of America

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  • John D. Gibbins,

    Affiliations: Epidemic Intelligence Service, Office of Workforce and Career Development, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America, Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio, United States of America

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  • Scott E. Brueck,

    Affiliation: Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio, United States of America

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  • Kirk E. Smith,

    Affiliation: Infectious Disease, Epidemiology, Prevention and Control Division, Minnesota Department of Health, Saint Paul, Minnesota, United States of America

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  • Richard N. Danila,

    Affiliation: Infectious Disease, Epidemiology, Prevention and Control Division, Minnesota Department of Health, Saint Paul, Minnesota, United States of America

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  • W. Ian Lipkin,

    Affiliation: Center for Infection and Immunity, Columbia University, New York, New York, United States of America

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  • Daniel H. Lachance,

    Affiliation: Department of Neurology, Mayo Clinic, Rochester, Minnesota, United States of America

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  • P. James. B. Dyck,

    Affiliation: Department of Neurology, Mayo Clinic, Rochester, Minnesota, United States of America

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  • Ruth Lynfield

    Affiliation: Infectious Disease, Epidemiology, Prevention and Control Division, Minnesota Department of Health, Saint Paul, Minnesota, United States of America

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  • Published: March 19, 2010
  • DOI: 10.1371/journal.pone.0009782

About the Authors

Stacy M. Holzbauer, Aaron S. DeVries, Christine H. Lees, Carlota Medus, Catherine A. Lexau, Kirk E. Smith, Richard N. Danila, Ruth Lynfield
Infectious Disease, Epidemiology, Prevention and Control Division, Minnesota Department of Health, Saint Paul, Minnesota, United States of America
Stacy M. Holzbauer, Jennifer Adjemian, Julie R. Harris, Bryan F. Buss, John D. Gibbins
Epidemic Intelligence Service, Office of Workforce and Career Development, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
James J. Sejvar, Jennifer H. McQuiston, Sergio E. Recuenco, Ermias D. Belay
Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector-borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
James F. Howell
Public Health Preparedness and Emergency Response, Indiana State Department of Health, Indianapolis, Indiana, United States of America
Bryan F. Buss
Division of Public Health, Nebraska Department of Health and Human Services, Lincoln, Nebraska, United States of America
Mady Hornig, W. Ian Lipkin
Center for Infection and Immunity, Columbia University, New York, New York, United States of America
John D. Gibbins, Scott E. Brueck
Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio, United States of America
Daniel H. Lachance, P. James. B. Dyck
Department of Neurology, Mayo Clinic, Rochester, Minnesota, United States of America

Corresponding Author

Email: Aaron.DeVries@state.mn.us

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SMH AD JJS CL JA JM CM CL JRH SR EDB JFH BFB MH JDG SEB KS RND WIL RL. Performed the experiments: SMH AD JJS CL JA JM CM CL JRH SR BFB MH JDG SEB DHL PJBD RL. Analyzed the data: SMH AD JJS CL JA JM CM CL JRH BFB MH JDG SEB KS RND RL. Contributed reagents/materials/analysis tools: SMH AD JJS CL JA JM CM CL JRH SR EDB JFH BFB MH JDG SEB KS RND WIL DHL PJBD RL. Wrote the paper: SMH AD JJS JA JRH MH KS RND RL.