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Research Article

Hepatocellular Carcinoma Displays Distinct DNA Methylation Signatures with Potential as Clinical Predictors

  • Hector Hernandez-Vargas equal contributor,

    equal contributor Contributed equally to this work with: Hector Hernandez-Vargas, Marie-Pierre Lambert

    Affiliation: Epigenetics Group, International Agency for Research on Cancer (IARC), Lyon, France

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  • Marie-Pierre Lambert equal contributor,

    equal contributor Contributed equally to this work with: Hector Hernandez-Vargas, Marie-Pierre Lambert

    Affiliation: Epigenetics Group, International Agency for Research on Cancer (IARC), Lyon, France

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  • Florence Le Calvez-Kelm,

    Affiliation: Genetic Cancer Susceptibility Group, International Agency for Research on Cancer (IARC), Lyon, France

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  • Géraldine Gouysse,

    Affiliation: Service d'Anatomie Pathologique, Edouard Herriot Hospital Lyon, Lyon, France

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  • Sandrine McKay-Chopin,

    Affiliation: Genetic Cancer Susceptibility Group, International Agency for Research on Cancer (IARC), Lyon, France

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  • Sean V. Tavtigian,

    Affiliation: Genetic Cancer Susceptibility Group, International Agency for Research on Cancer (IARC), Lyon, France

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  • Jean-Yves Scoazec,

    Affiliation: Service d'Anatomie Pathologique, Edouard Herriot Hospital Lyon, Lyon, France

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  • Zdenko Herceg mail

    herceg@iarc.fr

    Affiliation: Epigenetics Group, International Agency for Research on Cancer (IARC), Lyon, France

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  • Published: March 17, 2010
  • DOI: 10.1371/journal.pone.0009749
  • Featured in PLOS Collections

About the Authors

Hector Hernandez-Vargas, Marie-Pierre Lambert, Zdenko Herceg
Epigenetics Group, International Agency for Research on Cancer (IARC), Lyon, France
Florence Le Calvez-Kelm, Sandrine McKay-Chopin, Sean V. Tavtigian
Genetic Cancer Susceptibility Group, International Agency for Research on Cancer (IARC), Lyon, France
Géraldine Gouysse, Jean-Yves Scoazec
Service d'Anatomie Pathologique, Edouard Herriot Hospital Lyon, Lyon, France

Corresponding Author

Email: herceg@iarc.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HHV MPL ZH. Performed the experiments: HHV MPL FLCK SMC. Analyzed the data: HHV MPL. Contributed reagents/materials/analysis tools: JYS. Wrote the paper: HHV ZH. Processed the samples and the clinicopathological data: GG. Gave conceptual assistance: SVT JYS. Contributed to planning the experiments: SVT JYS.