A Monomeric Variant of Insulin Degrading Enzyme (IDE) Loses Its Regulatory Properties

Eun Suk Song; David W. Rodgers; Louis B. Hersh

doi:10.1371/journal.pone.0009719

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Open Access

Peer-reviewed

Research Article

A Monomeric Variant of Insulin Degrading Enzyme (IDE) Loses Its Regulatory Properties

Eun Suk Song,

Affiliation Department of Molecular and Cellular Biochemistry and the Center for Structural Biology, University of Kentucky, Lexington, Kentucky, United States of America
⨯
David W. Rodgers,

Affiliation Department of Molecular and Cellular Biochemistry and the Center for Structural Biology, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Louis B. Hersh

* E-mail: lhersh@uky.edu

Affiliation Department of Molecular and Cellular Biochemistry and the Center for Structural Biology, University of Kentucky, Lexington, Kentucky, United States of America
⨯

A Monomeric Variant of Insulin Degrading Enzyme (IDE) Loses Its Regulatory Properties

Eun Suk Song,
David W. Rodgers,
Louis B. Hersh

Published: March 16, 2010
https://doi.org/10.1371/journal.pone.0009719

About the Authors

Eun Suk Song

Affiliation Department of Molecular and Cellular Biochemistry and the Center for Structural Biology, University of Kentucky, Lexington, Kentucky, United States of America

David W. Rodgers

Affiliation Department of Molecular and Cellular Biochemistry and the Center for Structural Biology, University of Kentucky, Lexington, Kentucky, United States of America

Louis B. Hersh

* E-mail: lhersh@uky.edu

Affiliation Department of Molecular and Cellular Biochemistry and the Center for Structural Biology, University of Kentucky, Lexington, Kentucky, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ESS DWR LBH. Performed the experiments: ESS. Analyzed the data: ESS DWR LBH. Contributed reagents/materials/analysis tools: DWR. Wrote the paper: LBH.

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Dimers
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Enzymes
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Fluorescence
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Monomers
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Curve fitting
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Deletion mutagenesis
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Insulin
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Enzyme regulation
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