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Research Article

Pathogenic Polyglutamine Tracts Are Potent Inducers of Spontaneous Sup35 and Rnq1 Amyloidogenesis

  • Heike Goehler,

    Affiliation: Max Delbrueck Center for Molecular Medicine, Berlin, Germany

    Current address: Protagen AG, Dortmund, Germany

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  • Anja Dröge,

    Affiliation: Max Delbrueck Center for Molecular Medicine, Berlin, Germany

    Current address: SINA Science Services GmbH, Teltow, Germany

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  • Rudi Lurz,

    Affiliation: Max Planck Institute for Molecular Genetics, Berlin, Germany

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  • Sigrid Schnoegl,

    Affiliation: Max Delbrueck Center for Molecular Medicine, Berlin, Germany

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  • Yury O. Chernoff,

    Affiliation: School of Biology and Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, United States of America

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  • Erich E. Wanker mail

    ewanker@mdc-berlin.de

    Affiliation: Max Delbrueck Center for Molecular Medicine, Berlin, Germany

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  • Published: March 10, 2010
  • DOI: 10.1371/journal.pone.0009642

About the Authors

Heike Goehler, Anja Dröge, Sigrid Schnoegl, Erich E. Wanker
Max Delbrueck Center for Molecular Medicine, Berlin, Germany
Rudi Lurz
Max Planck Institute for Molecular Genetics, Berlin, Germany
Yury O. Chernoff
School of Biology and Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, United States of America

Corresponding Author

Email: ewanker@mdc-berlin.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HG AD EEW. Performed the experiments: HG AD RL. Analyzed the data: HG AD YOC EEW. Contributed reagents/materials/analysis tools: YOC. Wrote the paper: HG SS EEW.