About the Authors

Beatriz Martínez-Poveda

Affiliation Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Universidad de Málaga, Málaga, Spain

Luisella Verotta

medina@uma.es (MAM); luisella.verotta@unimi.it (LV)

Affiliation Dipartimento di Chimica Organica e Industriale, University of Milan, Milan, Italy

Ezio Bombardelli

Affiliation Indena S.p.A., Milan, Italy

Ana R. Quesada

Affiliations Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Universidad de Málaga, Málaga, Spain, Unidad 741 de CIBER “de Enfermedades Raras”, Málaga, Spain

Miguel Ángel Medina

medina@uma.es (MAM); luisella.verotta@unimi.it (LV)

Affiliations Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Universidad de Málaga, Málaga, Spain, Unidad 741 de CIBER “de Enfermedades Raras”, Málaga, Spain

Competing Interests

EB is affilitated to Indena S.p.A. (Milan, Italy). Dicyclohexylammonium hyperforinate (hyperforin-DCHA), a stable form of hyperforin (compound 1), was provided by Indena S.p.A. (Milan, Italy). However, Indena S.p.A. was not a funder for this study and had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Author Contributions

Conceived and designed the experiments: ARQ MAM. Performed the experiments: BMP. Analyzed the data: LV EB ARQ MAM. Contributed reagents/materials/analysis tools: LV EB. Wrote the paper: LV MAM.