About the Authors

Rita J. Guerreiro

Affiliations Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America, Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal

John Beck

Affiliation MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom

J. Raphael Gibbs

Affiliations Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America, Reta Lila Weston Institute and Departments of Molecular Neuroscience and Neurodegenerative Disease, Institute of Neurology, London, United Kingdom

Isabel Santana

Affiliation Neurology Service, Coimbra University Hospital, Coimbra, Portugal

Martin N. Rossor

Affiliation Dementia Research Centre, Institute of Neurology, University College London, London, United Kingdom

Jonathan M. Schott

Affiliation Dementia Research Centre, Institute of Neurology, University College London, London, United Kingdom

Michael A. Nalls

Affiliation Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

Helena Ribeiro

Affiliations Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal, Neurology Service, Coimbra University Hospital, Coimbra, Portugal

Beatriz Santiago

Affiliation Neurology Service, Coimbra University Hospital, Coimbra, Portugal

Nick C. Fox

Affiliation Dementia Research Centre, Institute of Neurology, University College London, London, United Kingdom

Catarina Oliveira

Affiliations Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal, Neurology Service, Coimbra University Hospital, Coimbra, Portugal

John Collinge

Affiliation MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom

Simon Mead

Affiliation MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom

Andrew Singleton

Singleta@mail.nih.gov

Affiliation Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

John Hardy

Affiliation Reta Lila Weston Institute and Departments of Molecular Neuroscience and Neurodegenerative Disease, Institute of Neurology, London, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SM AS JH. Performed the experiments: RJG JB. Analyzed the data: RJG JB JRG MAN. Contributed reagents/materials/analysis tools: JRG IS MR JS HR BS NCF CRO JC. Wrote the paper: RJG AS JH.