Advertisement
Research Article

Limitations of Ab Initio Predictions of Peptide Binding to MHC Class II Molecules

  • Hao Zhang equal contributor,

    equal contributor Contributed equally to this work with: Hao Zhang, Peng Wang, Nikitas Papangelopoulos

    Affiliation: Center for Biological Sequence Analysis, Department for Systems Biology, Technical University of Denmark, Lyngby, Denmark

    X
  • Peng Wang equal contributor,

    equal contributor Contributed equally to this work with: Hao Zhang, Peng Wang, Nikitas Papangelopoulos

    Affiliation: La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America

    X
  • Nikitas Papangelopoulos equal contributor,

    equal contributor Contributed equally to this work with: Hao Zhang, Peng Wang, Nikitas Papangelopoulos

    Affiliation: San Diego Supercomputer Center and Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California San Diego, San Diego, California, United States of America

    X
  • Ying Xu,

    Affiliation: Department of Biochemistry and Molecular Biology, Institute of Bioinformatics, University of Georgia, Athens, Georgia, United States of America

    X
  • Alessandro Sette,

    Affiliation: La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America

    X
  • Philip E. Bourne,

    Affiliation: San Diego Supercomputer Center and Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California San Diego, San Diego, California, United States of America

    X
  • Ole Lund,

    Affiliation: Center for Biological Sequence Analysis, Department for Systems Biology, Technical University of Denmark, Lyngby, Denmark

    X
  • Julia Ponomarenko,

    Affiliation: San Diego Supercomputer Center and Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California San Diego, San Diego, California, United States of America

    X
  • Morten Nielsen,

    Affiliation: Center for Biological Sequence Analysis, Department for Systems Biology, Technical University of Denmark, Lyngby, Denmark

    X
  • Bjoern Peters mail

    bpeters@liai.org

    Affiliation: La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America

    X
  • Published: February 17, 2010
  • DOI: 10.1371/journal.pone.0009272

About the Authors

Hao Zhang, Ole Lund, Morten Nielsen
Center for Biological Sequence Analysis, Department for Systems Biology, Technical University of Denmark, Lyngby, Denmark
Peng Wang, Alessandro Sette, Bjoern Peters
La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America
Nikitas Papangelopoulos, Philip E. Bourne, Julia Ponomarenko
San Diego Supercomputer Center and Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California San Diego, San Diego, California, United States of America
Ying Xu
Department of Biochemistry and Molecular Biology, Institute of Bioinformatics, University of Georgia, Athens, Georgia, United States of America

Corresponding Author

Email: bpeters@liai.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HZ PW NP OL JP MN BP. Performed the experiments: HZ PW NP. Analyzed the data: HZ PW NP YX AS PEB OL JP MN BP. Contributed reagents/materials/analysis tools: YX. Wrote the paper: HZ PW NP YX AS PEB OL JP MN BP.