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Research Article

Alternative Splicing and Extensive RNA Editing of Human TPH2 Transcripts

  • Maik Grohmann,

    Affiliations: Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany, Department of Biology, Chemistry, and Pharmacy, Free University Berlin, Berlin, Germany, Neuropsychiatry and Laboratory of Molecular Psychiatry, Charité-Universitätsmedizin, Berlin, Germany

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  • Paul Hammer,

    Affiliation: Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany

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  • Maria Walther,

    Affiliation: Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany

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  • Nils Paulmann,

    Affiliations: Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany, Department of Biology, Chemistry, and Pharmacy, Free University Berlin, Berlin, Germany

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  • Andreas Büttner,

    Affiliation: Institute for Legal Medicine, Ludwig Maximilians University, Munich, Germany

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  • Wolfgang Eisenmenger,

    Affiliation: Institute for Legal Medicine, Ludwig Maximilians University, Munich, Germany

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  • Thomas C. Baghai,

    Affiliation: Department of Psychiatry, Ludwig Maximilians University, Munich, Germany

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  • Cornelius Schüle,

    Affiliation: Department of Psychiatry, Ludwig Maximilians University, Munich, Germany

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  • Rainer Rupprecht,

    Affiliation: Department of Psychiatry, Ludwig Maximilians University, Munich, Germany

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  • Michael Bader,

    Affiliation: Laboratory of Molecular Biology of Peptide Hormones, Max Delbrück Center for Molecular Medicine, Berlin, Germany

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  • Brigitta Bondy,

    Affiliation: Department of Psychiatry, Ludwig Maximilians University, Munich, Germany

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  • Peter Zill,

    Affiliation: Department of Psychiatry, Ludwig Maximilians University, Munich, Germany

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  • Josef Priller equal contributor,

    equal contributor Contributed equally to this work with: Josef Priller, Diego J. Walther

    Affiliation: Neuropsychiatry and Laboratory of Molecular Psychiatry, Charité-Universitätsmedizin, Berlin, Germany

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  • Diego J. Walther equal contributor mail

    equal contributor Contributed equally to this work with: Josef Priller, Diego J. Walther

    dwalther@molgen.mpg.de

    Affiliation: Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany

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  • Published: January 29, 2010
  • DOI: 10.1371/journal.pone.0008956

About the Authors

Maik Grohmann, Paul Hammer, Maria Walther, Nils Paulmann, Diego J. Walther
Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany
Maik Grohmann, Nils Paulmann
Department of Biology, Chemistry, and Pharmacy, Free University Berlin, Berlin, Germany
Maik Grohmann, Josef Priller
Neuropsychiatry and Laboratory of Molecular Psychiatry, Charité-Universitätsmedizin, Berlin, Germany
Andreas Büttner, Wolfgang Eisenmenger
Institute for Legal Medicine, Ludwig Maximilians University, Munich, Germany
Michael Bader
Laboratory of Molecular Biology of Peptide Hormones, Max Delbrück Center for Molecular Medicine, Berlin, Germany
Thomas C. Baghai, Cornelius Schüle, Rainer Rupprecht, Brigitta Bondy, Peter Zill
Department of Psychiatry, Ludwig Maximilians University, Munich, Germany

Corresponding Author

Email: dwalther@molgen.mpg.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MG PZ JP DJW. Performed the experiments: MG PH MW NP BB PZ DJW. Analyzed the data: MG PH BB PZ JP DJW. Contributed reagents/materials/analysis tools: AB WE TCB CS RR MB BB PZ JP. Wrote the paper: MG DJW.