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Research Article

Defective Secretion of Islet Hormones in Chromogranin-B Deficient Mice

  • Stefanie Obermüller equal contributor,

    equal contributor Contributed equally to this work with: Stefanie Obermüller, Federico Calegari

    Affiliation: Department of Clinical Sciences-Malmö, Lund University, Malmö, Sweden

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  • Federico Calegari equal contributor,

    equal contributor Contributed equally to this work with: Stefanie Obermüller, Federico Calegari

    Affiliations: Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany, CNR Institute of Neuroscience, Department of Medical Pharmacology, University of Milan, Milan, Italy

    Current address: DFG Research Center and Cluster of Excellence for Regenerative Therapies Dresden, Technische Universität Dresden, c/o Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany

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  • Angus King,

    Affiliation: Department of Neurobiology, University of Heidelberg, Heidelberg, Germany

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  • Anders Lindqvist,

    Affiliation: Department of Clinical Sciences-Malmö, Lund University, Malmö, Sweden

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  • Ingmar Lundquist,

    Affiliation: Department of Clinical Sciences-Malmö, Lund University, Malmö, Sweden

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  • Albert Salehi,

    Affiliation: Department of Clinical Sciences-Malmö, Lund University, Malmö, Sweden

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  • Maura Francolini,

    Affiliation: CNR Institute of Neuroscience, Department of Medical Pharmacology, University of Milan, Milan, Italy

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  • Patrizia Rosa,

    Affiliation: CNR Institute of Neuroscience, Department of Medical Pharmacology, University of Milan, Milan, Italy

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  • Patrik Rorsman,

    Affiliation: Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Churchill Hospital, Oxford, United Kingdom

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  • Wieland B. Huttner mail,

    huttner@mpi-cbg.de (WBH); sebastian.barg@mcb.uu.se (SB)

    Affiliations: Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany, Department of Neurobiology, University of Heidelberg, Heidelberg, Germany

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  • Sebastian Barg mail

    huttner@mpi-cbg.de (WBH); sebastian.barg@mcb.uu.se (SB)

    Affiliations: Department of Clinical Sciences-Malmö, Lund University, Malmö, Sweden, Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden

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  • Published: January 28, 2010
  • DOI: 10.1371/journal.pone.0008936

About the Authors

Stefanie Obermüller, Anders Lindqvist, Ingmar Lundquist, Albert Salehi, Sebastian Barg
Department of Clinical Sciences-Malmö, Lund University, Malmö, Sweden
Federico Calegari, Wieland B. Huttner
Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
Federico Calegari, Maura Francolini, Patrizia Rosa
CNR Institute of Neuroscience, Department of Medical Pharmacology, University of Milan, Milan, Italy
Angus King, Wieland B. Huttner
Department of Neurobiology, University of Heidelberg, Heidelberg, Germany
Patrik Rorsman
Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Churchill Hospital, Oxford, United Kingdom
Sebastian Barg
Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SO FC AK PR WH SB. Performed the experiments: SO FC AK ABL IL AS MF SB. Analyzed the data: SO FC AK ABL SB. Contributed reagents/materials/analysis tools: FC PR. Wrote the paper: AK SB.