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Research Article

Double-Detargeted Oncolytic Adenovirus Shows Replication Arrest in Liver Cells and Retains Neuroendocrine Cell Killing Ability

  • Justyna Leja,

    Affiliation: Division of Clinical Immunology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden

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  • Berith Nilsson,

    Affiliation: Division of Clinical Immunology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden

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  • Di Yu,

    Affiliation: Division of Clinical Immunology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden

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  • Elisabet Gustafson,

    Affiliation: Department of Women's and Children's Health, University Hospital, Uppsala, Sweden

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  • Göran Åkerström,

    Affiliation: Department of Surgical Sciences, University Hospital, Uppsala, Sweden

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  • Kjell Öberg,

    Affiliation: Department of Medical Sciences, University Hospital, Uppsala, Sweden

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  • Valeria Giandomenico,

    Affiliation: Department of Medical Sciences, University Hospital, Uppsala, Sweden

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  • Magnus Essand mail

    magnus.essand@klinimm.uu.se

    Affiliation: Division of Clinical Immunology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden

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  • Published: January 27, 2010
  • DOI: 10.1371/journal.pone.0008916

About the Authors

Justyna Leja, Berith Nilsson, Di Yu, Magnus Essand
Division of Clinical Immunology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
Elisabet Gustafson
Department of Women's and Children's Health, University Hospital, Uppsala, Sweden
Göran Åkerström
Department of Surgical Sciences, University Hospital, Uppsala, Sweden
Kjell Öberg, Valeria Giandomenico
Department of Medical Sciences, University Hospital, Uppsala, Sweden

Corresponding Author

Email: magnus.essand@klinimm.uu.se

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JL ME. Performed the experiments: JL BN DY. Analyzed the data: JL KÖ VG. Contributed reagents/materials/analysis tools: EG GÅ. Wrote the paper: JL ME.