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Research Article

Huntingtin Interacts with the Cue Domain of gp78 and Inhibits gp78 Binding to Ubiquitin and p97/VCP

  • Hui Yang,

    Affiliation: Center for Biomedical Engineering and Technology, University of Maryland, Baltimore, Maryland, United States of America

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  • Chao Liu,

    Affiliation: Center for Biomedical Engineering and Technology, University of Maryland, Baltimore, Maryland, United States of America

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  • Yongwang Zhong,

    Affiliation: Center for Biomedical Engineering and Technology, University of Maryland, Baltimore, Maryland, United States of America

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  • Shouqing Luo,

    Affiliation: Department of Medical Genetics, Cambridge Institute for Medical Research, Cambridge, United Kingdom

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  • Mervyn J. Monteiro,

    Affiliation: Center for Biomedical Engineering and Technology, University of Maryland, Baltimore, Maryland, United States of America

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  • Shengyun Fang mail

    fangs@umbi.umd.edu

    Affiliation: Center for Biomedical Engineering and Technology, University of Maryland, Baltimore, Maryland, United States of America

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  • Published: January 26, 2010
  • DOI: 10.1371/journal.pone.0008905

About the Authors

Hui Yang, Chao Liu, Yongwang Zhong, Mervyn J. Monteiro, Shengyun Fang
Center for Biomedical Engineering and Technology, University of Maryland, Baltimore, Maryland, United States of America
Shouqing Luo
Department of Medical Genetics, Cambridge Institute for Medical Research, Cambridge, United Kingdom

Corresponding Author

Email: fangs@umbi.umd.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HY SF. Performed the experiments: HY CL YZ. Analyzed the data: HY SL MJM SF. Contributed reagents/materials/analysis tools: SL. Wrote the paper: HY SF.