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Research Article

Measuring the Pharmacodynamic Effects of a Novel Hsp90 Inhibitor on HER2/neu Expression in Mice Using 89Zr-DFO-Trastuzumab

  • Jason P. Holland,

    Affiliation: Radiochemistry Service, Department of Radiology, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Cancer Center, New York, New York, United States of America

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  • Eloisi Caldas-Lopes,

    Affiliation: Program in Molecular Pharmacology and Chemistry, Sloan Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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  • Vadim Divilov,

    Affiliation: Radiochemistry Service, Department of Radiology, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Cancer Center, New York, New York, United States of America

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  • Valerie A. Longo,

    Affiliation: Small-Animal Imaging Core Facility, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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  • Tony Taldone,

    Affiliation: Program in Molecular Pharmacology and Chemistry, Sloan Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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  • Danuta Zatorska,

    Affiliation: Program in Molecular Pharmacology and Chemistry, Sloan Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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  • Gabriela Chiosis,

    Affiliation: Program in Molecular Pharmacology and Chemistry, Sloan Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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  • Jason S. Lewis mail

    lewisj2@mskcc.org

    Affiliations: Radiochemistry Service, Department of Radiology, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Cancer Center, New York, New York, United States of America, Program in Molecular Pharmacology and Chemistry, Sloan Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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  • Published: January 25, 2010
  • DOI: 10.1371/journal.pone.0008859

About the Authors

Jason P. Holland, Vadim Divilov, Jason S. Lewis
Radiochemistry Service, Department of Radiology, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Cancer Center, New York, New York, United States of America
Eloisi Caldas-Lopes, Tony Taldone, Danuta Zatorska, Gabriela Chiosis, Jason S. Lewis
Program in Molecular Pharmacology and Chemistry, Sloan Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
Valerie A. Longo
Small-Animal Imaging Core Facility, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Corresponding Author

Email: lewisj2@mskcc.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JPH ECL GC JSL. Performed the experiments: JPH ECL VD VAL TT DZ. Analyzed the data: JPH ECL VD VAL GC JSL. Contributed reagents/materials/analysis tools: JPH TT DZ GC. Wrote the paper: JPH GC JSL.