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Research Article

Urinary Volatile Compounds as Biomarkers for Lung Cancer: A Proof of Principle Study Using Odor Signatures in Mouse Models of Lung Cancer

  • Koichi Matsumura,

    Affiliation: Monell Chemical Senses Center, Philadelphia, Pennsylvania, United States of America

    Current address: Department of Integrated Biosciences, The University of Tokyo, Chiba, Japan

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  • Maryanne Opiekun,

    Affiliation: Monell Chemical Senses Center, Philadelphia, Pennsylvania, United States of America

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  • Hiroaki Oka,

    Affiliation: Panasonic Corporation, Kyoto, Japan

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  • Anil Vachani,

    Affiliation: University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, United States of America

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  • Steven M. Albelda,

    Affiliation: University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, United States of America

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  • Kunio Yamazaki,

    Affiliation: Monell Chemical Senses Center, Philadelphia, Pennsylvania, United States of America

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  • Gary K. Beauchamp mail

    beauchamp@monell.org

    Affiliation: Monell Chemical Senses Center, Philadelphia, Pennsylvania, United States of America

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  • Published: January 27, 2010
  • DOI: 10.1371/journal.pone.0008819

About the Authors

Koichi Matsumura, Maryanne Opiekun, Kunio Yamazaki, Gary K. Beauchamp
Monell Chemical Senses Center, Philadelphia, Pennsylvania, United States of America
Hiroaki Oka
Panasonic Corporation, Kyoto, Japan
Anil Vachani, Steven M. Albelda
University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, United States of America

Corresponding Author

Email: beauchamp@monell.org

Competing Interests

This research was supported by a grant from the Panasonic Corporation. The authors declare no other competing interests. There are no patents or patents pending based on the work and there are no products arising from the work under development. None of the authors, aside from one co-author who is employed by Panasonic (Dr. Oka), have any financial relationships that could be perceived as relevant including stock ownership, consultancy agreements, or travel grants or honoraria. Dr. Oka helped conceive of the original idea for this work and reviewed the manuscript but the other coauthors designed the study, conducted it, analyzed the data and wrote the manuscript.

Author Contributions

Conceived and designed the experiments: KM HO SMA KY GKB. Performed the experiments: KM MO. Analyzed the data: KM. Contributed reagents/materials/analysis tools: KM HO AV SMA. Wrote the paper: KM AV SMA KY GKB.