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Research Article

Time-Resolved and Tissue-Specific Systems Analysis of the Pathogenesis of Insulin Resistance

  • Robert Kleemann mail,

    Robert.Kleemann@tno.nl

    Affiliations: Quality of Life, Vascular and Metabolic Disease, TNO, Leiden, The Netherlands, Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands, Top Institute Food and Nutrition, Wageningen, The Netherlands

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  • Marjan van Erk,

    Affiliation: Quality of Life, Physiological Genomics, TNO, Zeist, The Netherlands

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  • Lars Verschuren,

    Affiliations: Quality of Life, Vascular and Metabolic Disease, TNO, Leiden, The Netherlands, Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands

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  • Anita M. van den Hoek,

    Affiliation: Quality of Life, Vascular and Metabolic Disease, TNO, Leiden, The Netherlands

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  • Maud Koek,

    Affiliation: Quality of Life, Analytical Research, TNO, Zeist, The Netherlands

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  • Peter Y. Wielinga,

    Affiliations: Quality of Life, Vascular and Metabolic Disease, TNO, Leiden, The Netherlands, Top Institute Food and Nutrition, Wageningen, The Netherlands

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  • Annie Jie,

    Affiliation: Quality of Life, Vascular and Metabolic Disease, TNO, Leiden, The Netherlands

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  • Linette Pellis,

    Affiliation: Quality of Life, Physiological Genomics, TNO, Zeist, The Netherlands

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  • Ivana Bobeldijk-Pastorova,

    Affiliation: Quality of Life, Analytical Research, TNO, Zeist, The Netherlands

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  • Thomas Kelder,

    Affiliation: Department of Bioinformatics, Maastricht University, Maastricht, The Netherlands

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  • Karin Toet,

    Affiliations: Quality of Life, Vascular and Metabolic Disease, TNO, Leiden, The Netherlands, Top Institute Food and Nutrition, Wageningen, The Netherlands

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  • Suzan Wopereis,

    Affiliation: Quality of Life, Physiological Genomics, TNO, Zeist, The Netherlands

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  • Nicole Cnubben,

    Affiliation: Quality of Life, Physiological Genomics, TNO, Zeist, The Netherlands

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  • Chris Evelo,

    Affiliation: Department of Bioinformatics, Maastricht University, Maastricht, The Netherlands

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  • Ben van Ommen,

    Affiliation: Quality of Life, Physiological Genomics, TNO, Zeist, The Netherlands

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  • Teake Kooistra

    Affiliation: Quality of Life, Vascular and Metabolic Disease, TNO, Leiden, The Netherlands

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  • Published: January 21, 2010
  • DOI: 10.1371/journal.pone.0008817

About the Authors

Robert Kleemann, Lars Verschuren, Anita M. van den Hoek, Peter Y. Wielinga, Annie Jie, Karin Toet, Teake Kooistra
Quality of Life, Vascular and Metabolic Disease, TNO, Leiden, The Netherlands
Robert Kleemann, Lars Verschuren
Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands
Marjan van Erk, Linette Pellis, Suzan Wopereis, Nicole Cnubben, Ben van Ommen
Quality of Life, Physiological Genomics, TNO, Zeist, The Netherlands
Robert Kleemann, Peter Y. Wielinga, Karin Toet
Top Institute Food and Nutrition, Wageningen, The Netherlands
Thomas Kelder, Chris Evelo
Department of Bioinformatics, Maastricht University, Maastricht, The Netherlands
Maud Koek, Ivana Bobeldijk-Pastorova
Quality of Life, Analytical Research, TNO, Zeist, The Netherlands

Corresponding Author

Email: Robert.Kleemann@tno.nl

Competing Interests

Authors employed by TNO (R.K., M.v.E., A.J., L.V., A.M.v.d.H., M.K, P.Y.W, L.P., I.B.–P., K.T., S.W., N.C., B.v.O., and T.K.) and the Top Institute Food and Nutrition (R.K., P.Y.W., and K.T.) have a potential conflict of interest as their organizations may benefit from a product or patent generated on the basis of the published data. In these cases, the authors will however not receive additional salary, additional personal income, or any form of financial support.

Author Contributions

Conceived and designed the experiments: RK AMvdH BvO TK. Performed the experiments: RK LV AMvdH MK PYW AJ IBP KT. Analyzed the data: RK MvE LV AMvdH MK PYW AJ LP IBP TK KT SW NC CE TK. Contributed reagents/materials/analysis tools: LP IBP NC CE BvO TK. Wrote the paper: RK TK. Extensive reviewing and editing of the paper: MvE.