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Research Article

MHC Class II Molecules Enhance Toll-Like Receptor Mediated Innate Immune Responses

  • Remo Frei mail,

    remo.frei@kispi.uzh.ch (RF); roger.lauener@hgk.ch (RPL)

    Affiliation: Division of Immunology/Allergology, University of Zurich, Children's Hospital, Zurich, Switzerland

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  • Johanna Steinle,

    Affiliation: Division of Immunology/Allergology, University of Zurich, Children's Hospital, Zurich, Switzerland

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  • Thomas Birchler,

    Affiliation: Section of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland

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  • Susanne Loeliger,

    Affiliation: Division of Immunology/Allergology, University of Zurich, Children's Hospital, Zurich, Switzerland

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  • Caroline Roduit,

    Affiliation: Division of Immunology/Allergology, University of Zurich, Children's Hospital, Zurich, Switzerland

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  • Dirk Steinhoff,

    Affiliation: Division of Immunology/Allergology, University of Zurich, Children's Hospital, Zurich, Switzerland

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  • Reinhart Seibl,

    Affiliation: Division of Immunology/Allergology, University of Zurich, Children's Hospital, Zurich, Switzerland

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  • Katja Büchner,

    Affiliation: Division of Immunology/Allergology, University of Zurich, Children's Hospital, Zurich, Switzerland

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  • Reinhard Seger,

    Affiliation: Division of Immunology/Allergology, University of Zurich, Children's Hospital, Zurich, Switzerland

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  • Walter Reith,

    Affiliation: Department of Pathology and Immunology, University of Geneva Medical School, Geneva, Switzerland

    X
  • Roger P. Lauener mail

    remo.frei@kispi.uzh.ch (RF); roger.lauener@hgk.ch (RPL)

    Affiliation: Division of Immunology/Allergology, University of Zurich, Children's Hospital, Zurich, Switzerland

    X
  • Published: January 20, 2010
  • DOI: 10.1371/journal.pone.0008808

About the Authors

Remo Frei, Johanna Steinle, Susanne Loeliger, Caroline Roduit, Dirk Steinhoff, Reinhart Seibl, Katja Büchner, Reinhard Seger, Roger P. Lauener
Division of Immunology/Allergology, University of Zurich, Children's Hospital, Zurich, Switzerland
Thomas Birchler
Section of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland
Walter Reith
Department of Pathology and Immunology, University of Geneva Medical School, Geneva, Switzerland

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RF RPL. Performed the experiments: RF TB SL DS RS KB. Analyzed the data: RF JS TB SL CR DS RS KB RPL. Contributed reagents/materials/analysis tools: RF TB RS WR RPL. Wrote the paper: RF JS WR RPL.