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Research Article

Two Multiplex Assays That Simultaneously Identify 22 Possible Mutation Sites in the KRAS, BRAF, NRAS and PIK3CA Genes

  • Irene Lurkin,

    Affiliation: Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands

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  • Robert Stoehr,

    Affiliation: Institute of Pathology, University of Erlangen, Erlangen, Germany

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  • Carolyn D. Hurst,

    Affiliation: Cancer Research UK Clinical Centre, Leeds Institute of Molecular Medicine, St. James's University Hospital, Leeds, United Kingdom

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  • Angela A. G. van Tilborg,

    Affiliation: Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands

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  • Margaret A. Knowles,

    Affiliation: Cancer Research UK Clinical Centre, Leeds Institute of Molecular Medicine, St. James's University Hospital, Leeds, United Kingdom

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  • Arndt Hartmann,

    Affiliation: Institute of Pathology, University of Erlangen, Erlangen, Germany

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  • Ellen C. Zwarthoff mail

    e.zwarthoff@erasmusmc.nl

    Affiliation: Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands

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  • Published: January 21, 2010
  • DOI: 10.1371/journal.pone.0008802

About the Authors

Irene Lurkin, Angela A. G. van Tilborg, Ellen C. Zwarthoff
Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands
Robert Stoehr, Arndt Hartmann
Institute of Pathology, University of Erlangen, Erlangen, Germany
Carolyn D. Hurst, Margaret A. Knowles
Cancer Research UK Clinical Centre, Leeds Institute of Molecular Medicine, St. James's University Hospital, Leeds, United Kingdom

Corresponding Author

Email: e.zwarthoff@erasmusmc.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: IL RS CH AAGvT MK AH ECZ. Performed the experiments: IL RS. Analyzed the data: IL RS CH AAGvT MK AH ECZ. Contributed reagents/materials/analysis tools: RS CH AH. Wrote the paper: IL AAGvT MK AH ECZ.