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Research Article

Hypothalamic-Specific Manipulation of Fto, the Ortholog of the Human Obesity Gene FTO, Affects Food Intake in Rats

  • Yi-Chun Loraine Tung,

    Affiliation: University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Treatment Centre, Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Eduard Ayuso equal contributor,

    equal contributor Contributed equally to this work with: Eduard Ayuso, Xiaoye Shan

    Affiliations: Center of Animal Biotechnology and Gene Therapy and Department of Biochemistry and Molecular Biology, School of Veterinary Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain

    X
  • Xiaoye Shan equal contributor,

    equal contributor Contributed equally to this work with: Eduard Ayuso, Xiaoye Shan

    Affiliation: University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Treatment Centre, Addenbrooke's Hospital, Cambridge, United Kingdom

    X
  • Fatima Bosch,

    Affiliations: Center of Animal Biotechnology and Gene Therapy and Department of Biochemistry and Molecular Biology, School of Veterinary Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain

    X
  • Stephen O'Rahilly mail,

    so104@medschl.cam.ac.uk (SO); gshy2@cam.ac.uk (GSHY)

    Affiliation: University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Treatment Centre, Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Anthony P. Coll,

    Affiliation: University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Treatment Centre, Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Giles S. H. Yeo mail

    so104@medschl.cam.ac.uk (SO); gshy2@cam.ac.uk (GSHY)

    Affiliation: University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Treatment Centre, Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Published: January 19, 2010
  • DOI: 10.1371/journal.pone.0008771

About the Authors

Yi-Chun Loraine Tung, Xiaoye Shan, Stephen O'Rahilly, Anthony P. Coll, Giles S. H. Yeo
University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Treatment Centre, Addenbrooke's Hospital, Cambridge, United Kingdom
Eduard Ayuso, Fatima Bosch
Center of Animal Biotechnology and Gene Therapy and Department of Biochemistry and Molecular Biology, School of Veterinary Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain
Eduard Ayuso, Fatima Bosch
CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YCLT EA FB SO APC GSHY. Performed the experiments: YCLT XS. Analyzed the data: YCLT. Contributed reagents/materials/analysis tools: YCLT EA FB. Wrote the paper: YCLT SO APC GSHY.