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Research Article

Opiate-Induced Suppression of Rat Hypoglossal Motoneuron Activity and Its Reversal by Ampakine Therapy

  • Amanda R. Lorier,

    Affiliation: Division of Neuroscience, University of Alberta, Edmonton, Canada

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  • Gregory D. Funk,

    Affiliation: Division of Neuroscience, University of Alberta, Edmonton, Canada

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  • John J. Greer mail

    john.greer@ualberta.ca

    Affiliation: Division of Neuroscience, University of Alberta, Edmonton, Canada

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  • Published: January 19, 2010
  • DOI: 10.1371/journal.pone.0008766

About the Authors

Amanda R. Lorier, Gregory D. Funk, John J. Greer
Division of Neuroscience, University of Alberta, Edmonton, Canada

Corresponding Author

Email: john.greer@ualberta.ca

Competing Interests

Ampakines used in the study were provided free of charge by Cortex Pharmaceuticals. However, Cortex Pharmaceuticals was not involved in any aspect of study design, experimentation, data analysis, or manuscript preparation. Fundings for all other aspects of the study, beyond providing amapakines, were from government funding agencies Canadian Institutes for Health Research and Alberta Heritage Foundation for Medical Research. United States provisional patent application S/N 60/824,245 ‘Method of Inhibiting Respiratory Depression Using Ampakines’. The University of Alberta has granted Cortex Pharmaceuticals a worldwide exclusive license to the patent rights covered by this application.

Author Contributions

Conceived and designed the experiments: GDF JJG. Performed the experiments: ARL. Analyzed the data: ARL. Wrote the paper: ARL GDF JJG.